4-[5-(Pyridin-4-yl)-1H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile (FYX-051) is a potent inhibitor of bovine milk xanthine oxidoreductase (XOR). Steady-state kinetics study showed that it initially behaved as a competitive-type inhibitor with a K(i) value of 5.7 × 10(-9) M, then after a few minutes it formed a tight complex with XOR via a Mo-oxygen-carbon atom covalent linkage, as reported previ...

Memokath-051 is a thermo-expandable, nickel-titanium alloy spiral stent used to treat ureteric obstruction resulting from malignant or benign strictures. The National Institute for Health and Care Excellence (NICE) selected Memokath-051 for evaluation. The company, PNN Medical, claimed Memokath-051 has clinical superiority and cost savings compared with double-J stents. It identified five studi...

In humans, orally administered 4-(5-pyridin-4-yl-1H-[1,2,4]triazol-3-yl) pyridine-2-carbonitrile (FYX-051) is excreted mainly as triazole N(1)- and N(2)-glucuronides in urine. It is important to determine the enzyme(s) that catalyze the metabolism of a new drug to estimate individual differences and/or drug-drug interactions. Therefore, the characterization and mechanism of these glucuronidatio...

Gabriele Grandi 1,*, Jelena Loncarski 2 and Milan Srndovic 1 1 Department of Electrical, Electronic, and Information Engineering, University of Bologna, Viale Risorgimento 2, Bologna 40136, Italy; milan.srndovic2@unibo.it 2 Department of Engineering Sciences, Ångström Laboratory, Uppsala University, Lägerhyddsvägen 1, Box 534, Uppsala S-751 21, Sweden; jelena.loncarski@angstrom.uu.se * Correspo...

The environment in which foods are prepared and handled can have significant impact on microbiological safety and quality, particularly for ready-to-eat foods. Outbreaks associated with Listeria monocytogenes and salmonellae have led to an increasing awareness that certain pathogens can persist in food processing environments, contaminate foods as they are being processed and lead to foodborne ...

119 Correspondence to: Young Hoon Roh, Department of Surgery, Dong-A University College of Medicine, 1, 3-ga, Dongdaesin-dong, Seo-gu, Busan 602-714, Korea. Tel: 051-240-2619, Fax: 051-247-9316, E-mail: gsryh@dau.ac.kr Received July 20, 2010, Accepted September 7, 2010 This work was supported by the Dong-A University research fund. The Learning Curve for Single-Port Laparoscopic Cholecystectomy...

In this paper a two-sector dynamic model of business ‡uctuations is presented. It is a disequilibrium dynamic model with two laws of evolution (dynamic laws) built into it: prices of commodities change according to the market disequilibrium of supply and demand, while quantities change according to the stock disequilibrium and the shifting of the degree of utilization of productive capacity awa...

Milan Srndovic 1,*, Yakov L. Familiant 2, Gabriele Grandi 1 and Alex Ruderman 2 1 Department of Electrical, Electronic, and Information Engineering, University of Bologna, Viale Risorgimento 2, Bologna 40136, Italy; gabriele.grandi@unibo.it 2 Power Electronics Research Lab, Nazarbayev University, Kabanbay Batyr Avenue 57, Astana 010000, Kazakhstan; yakov.familiant@nu.edu.kz (Y.L.F.); alexander....