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BACKGROUND The association of HLA A*02 with multiple sclerosis (MS) was recently confirmed by the authors, and it was observed that the combined presence of HLA Cw*05 significantly enhanced (threefold) the protective effect of HLA A*02. OBJECTIVES AND METHODS Since A*02-Cw*05 is carried by two HLA extended haplotypes characterised by the B*4402 and B*1801 alleles, respectively, the associatio...
Abstract Background : Suicide is a complex phenomenon determined by the interaction of various risk factors. The Major Histocompatibility Complex most polymorphic gene cluster entire human genome, being linked to both regulation immune system and psychiatric diseases. aim this study was identify HLA-DQB1 DRB1 alleles genotypes susceptible influence suicidal behavior. Methods We explored associa...
The well-characterized association between HLA-B*27:05 and protection against HIV disease progression has been linked to immunodominant HLA-B*27:05-restricted CD8+ T-cell responses toward the conserved Gag KK10 (residues 263 to 272) and polymerase (Pol) KY9 (residues 901 to 909) epitopes. We studied the impact of the 3 amino acid differences between HLA-B*27:05 and the closely related HLA-B*27:...
In this paper, we first identify eight major design challenges imposed by the next generation space protocols design. Second, we further defined a design evaluation framework based on the space protocol design challenges. Third, we critically evaluate the design of seven leading protocols architectures presented in [RHC 05] [HCP 05] [Bergamo 05] [BCDFHSW 02] [BH 02] [Israel 02] [LB 06] using th...
1 This work was supported in part by RFBR, Grants: 05-02-08016; 04-02-16576; 05-02-08240. Abstract – The report presents a brief review of research and developments, which made it possible to create during the number of years a series of the pulse-periodic millimeter wave range nanosecond and subnanosecond relativistic HPM generators. The devices are based on a compact high-current electron acc...
INTRODUCTION Genetic predisposition to multiple sclerosis (MS) in Sardinia (Italy) has been associated with five DRB1*-DQB1* haplotypes of the human leukocyte antigen (HLA). Given the complexity of these associations, an in-depth re-analysis was performed with the specific aims of confirming the haplotype associations; establishing the independence of the associated haplotypes; and assessing pa...
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