2:30 p.m. 2:45 p.m. OF MICE, MEN AND PIGS: LOSS OF CFTR PRODUCES ABNORMAL TRACHEAL DEVELOPMENT D.K. Meyerholz, S. Ramachandran, D.A. Stoltz, M.J. Welsh, and P.B. McCray, Jr. Departments of Pathology, Pediatrics, Internal Medicine, Molecular Physiology and Biophysics, and Howard Hughes Medical Institute, Roy Carver College of Medicine, University of Iowa, Iowa City, IA Keyword: Respiratory Syste...

The linker histones (H1 or H5) which play a key role in the folding of chromatin, are general repressors of gene expression. Nuclei of the mature chicken erythrocytes (and in some mammalian cells) contain both of them. Although the interaction of H5 with DNA is stronger than that of H1, it does not prevent the transcription of some erythroid-specific genes. It has been shown that some modificat...