The effect of a selective thromboxane synthetase inhibitor, OKY-046, and a selective 5-lipoxygenase inhibitor, AA-861, on bronchial responsiveness to acetylcholine was studied in 23 asthmatic subjects. The provocative concentration of acetylcholine producing a 20% fall in forced expiratory volume in one second (PC20 FEV1) was measured before and after oral administration of OKY-046 (3000 mg ove...

We examined the effect of thromboxane A2 (TXA2) synthetase inhibitor, OKY-046, on bronchoconstriction induced by antigen and various spasmogenic mediators in guinea pigs in vivo. Further, inhibitory activities of OKY-046 on contractions of isolated tracheae and lung parenchymal strips induced by various contractile agents were also investigated in vitro. OKY-046, but not indomethacin, significa...

The experience of conscious will is the feeling that we are doing things. This feeling occurs for many things we do, conveying to us again and again the sense that we consciously cause our actions. But the feeling may not be a true reading of what is happening in our minds, brains, and bodies as our actions are produced. The feeling of conscious will can be fooled. This happens in clinical diso...

Abstract Many high-yielding varieties of rice have been released, but generally lack good quality. This study aimed to examine the agronomic performance several new plant types black F3 lines at two medium altitude. The research was carried out on fields in Tallunglipu District, North Toraja Regency with an altitude 850 m above sea level. took place from May 2020 November 2022. used Single Seed...

Effects of OKY-046, a selective inhibitor of thromboxane (TX)A2 synthetase and a platelet aggregation inhibitor, on in vitro and in vivo models of cerebral vasospasm were studied. The contraction of the isolated rabbit basilar artery by an exposure to 1.0 ml of whole rabbit blood plus 0.05 or 0.1 units/ml of thrombin was diminished by the treatment with 10(-4) M of OKY-046 and/or 10(-6) M of ci...

We examine the power of Boolean functions with low L 1 norms in several settings. In large part of the recent literature, the degree of a polynomial which represents a Boolean function in some way was chosen to be the measure of the complexity of the Boolean function (see, e. have high degree, but small L 1 norms. So, in conjunction with communication complexity, instead of the degree, the L 1 ...

In vortex particle methods one is concerned with the problem of clustering and depletion of particles in different regions of the flow. The overlap of the vortex blobs is indeed of primary importance for the convergence of the method. In this paper we consider face-centred cubic (FCC) lattices for particle redistribution in three dimensions. This lattice is in fact the most natural way to pack ...

We encountered an unfamiliar ascomycete fruiting body, fitting characteristics of the genus Kretzschmaria, which features in a stipitate ascigerous stroma with carbonaceous interior and disintegrating perithecia. In this study, we report and characterize a new species of the decaying fungus. Compared to other species, one of the notable features of this specimen (TPML150908-046) is its stromata...

Immersion tin is widely used as lead free surface finish in the printed circuit board technology. Tin prevents the underlying copper from corrosion and preserves its solderability during a long storage and lead-free assembly processes. In the paper immersion tin coatings of different thickness (0.2 ÷ 1.5 μm) deposited on copper foil from methanelulphonic bath were investigated. The layers were ...