Henry D. I. Abarbanel, 1,2 Nikolai F. Rulkov, 2 and Mikhail M. Sushchik 3 Department of Physics and Marine Physical Laboratory, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093-0402 Institute for Nonlinear Science, University of California, San Diego, La Jolla, California 92093-0402 Department of Physics and Institute for Nonlinear Science, Un...

Mikhail Rabinovich, Ramón Huerta, Maxim Bazhenov, Alexander K. Kozlov, and Henry D. I. Abarbanel* Institute for Nonlinear Science, University of California, San Diego, La Jolla, California 92093-0402 Department of Computer Engineering, Universidad Autónoma de Madrid, 29049 Madrid, Spain Howard Hughes Medical Institute, The Salk Institute, Computational Neurobiology Laboratory, La Jolla, Califor...

BACKGROUND HLA-DRB1 0401 is associated with susceptibility, while HLA-DRB1 0402 is associated with resistance to developing rheumatoid arthritis (RA) and collagen-induced arthritis in humans and transgenic mice respectively. The influence of gut-joint axis has been suggested in RA, though not yet proven. METHODOLOGY/PRINCIPAL FINDINGS We have used HLA transgenic mice carrying arthritis suscep...

ecent years have witnessed steady levels of most sexually transmitted diseases (STDs), along with a significant resurgence in syphilis cases.1,2 At the same time, diagnostic tests for STDs have increased in number and diversity. This article summarizes the most important standard tests for common sexually transmitted infections in adults, highlighting newer tests designed to address challenges ...

We present results of multi-frequency VLBA observations of the compact symmetric object (CSO) 0402+379. The parsec-scale morphology of 0402+379 allows us to confirm it as a CSO, while VLA data clearly show the presence of kiloparsec-scale structure. Thus, 0402+379 is only the second known CSO to possess large scale structure. Another puzzling morphological characteristic found from our observat...

To investigate the role of HLA-DR4 in predisposition to arthritis, we generated transgenic mice carrying DRB1*0401 and DRB1*0402 genes. We have previously shown that DRB1*0401 molecule renders B10.RQB3 (H2A(q)) mice susceptible to porcine and human type II collagen-induced arthritis. We report that the introduction of DRB1*0402 transgene does not lead to development of arthritis in mice when th...

OBJECTIVE To determine the relative risk associated with DPA1 and DPB1 alleles and haplotypes in type 1 diabetes. RESEARCH DESIGN AND METHODS The frequency of DPA1 and DPB1 alleles and haplotypes in type 1 diabetic patients was compared to the family based control frequency in 1,771 families directly and conditional on HLA (B)-DRB1-DQA1-DQB1 linkage disequilibrium. A relative predispositional...

BACKGROUND AND OBJECTIVES The HLA system plays a central role in the distinction between self antigens and non-self antigens. This study aimed to investigate the association between HLA genes and the outcomes of patients with ANCA-associated vasculitis (AAV). DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS This study recruited 152 consecutive Chinese patients with AAV. The predictive value of t...

Cross-reactivity or molecular mimicry may be one of the underlying mechanisms involved in the etiopathogenesis of rheumatoid arthritis (RA). Antiserum against the RA susceptibility sequence EQKRAA was shown to bind to a similar peptide ESRRAL present in the hemolysin of the gram-negative bacterium Proteus mirabilis, and an anti-ESRRAL serum reacted with EQKRAA. There was no reactivity with eith...

We previously showed that microparts can be fed along a saw-toothed surface using simple planar symmetric vibrations. Microparts move forward because they adhere to the saw-toothed surface asymmetrically. We used saw-toothed silicon wafers fabricated by a dicing saw applying bevel type blades. We then studied the movement of 2012-type capacitors (size:2.0× 1.2× 0.6 mm, weight:7.5 mg) and 0603-t...