The purpose of this study was to determine the mechanism of action of SPI-0211 (lubiprostone), a novel bicyclic fatty acid in development for the treatment of bowel dysfunction. Adult rabbit intestine was shown to contain mRNA for ClC-2 using RT-PCR, Northern blot analysis, and in situ hybridization. T84 cells grown to confluence on permeable supports were shown to express ClC-2 channel protein...

Cuppoletti, John, Danuta H. Malinowska, Kirti P. Tewari, Qiu-ju Li, Ann M. Sherry, Myra L. Patchen, and Ryuji Ueno. SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents. Am J Physiol Cell Physiol 287: C1173– C1183, 2004. First published June 22, 2004; doi:10.1152/ajpcell. 00528.2003.—The purpose of this study was to determine the mechanism of action of SP...

The purpose of this study was to determine the mechanism of action of SPI-0211 (Lubiprostone), a novel bicyclic fatty acid, under development for the treatment of bowel dysfunction. Adult rabbit intestine was shown to contain mRNA for ClC-2 by RT-PCR, Northern analysis, and in situ hybridization. T84 cells grown to confluence on permeable supports were shown to express ClC-2 channel protein in ...

Juan J. Bravo-Suárez Centro de Investigaciones en Catálisis, Escuela de Ingeniería Química, Universidad Industrial de Santander, A.A. 678 Bucaramanga, Colombia and Environmental Catalysis and Nanomaterials Laboratory, Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061-0211 Edgar A. Páez-Mozo Centro de Investigaciones en Catálisis,...

Juan J. Bravo-Suárez Centro de Investigaciones en Catálisis, Escuela de Ingeniería Química, Universidad Industrial de Santander, A.A. 678 Bucaramanga, Colombia and Environmental Catalysis and Nanomaterials Laboratory, Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061-0211 Edgar A. Páez-Mozo Centro de Investigaciones en Catálisis,...

FOUNDATIONAL PLATFORM Service The OUSCM will deliver evidence-based, Community Collaboration The OUSCM will accountable and affordable health care that meets the become a widely known leader in building healthy needs and values of the residents of our community. communities through relationship-centered collaboration. Education We will develop the profession of Positive Institutional Culture Th...

Abstract The acoustic emission testing standards ASTM E1930, BS EN 15856, JB/T 10764 and Q/SY GD 0211 for atmospheric storage tank are compared analysed. Combined with production practice, the revision direction reference suggestions of were proposed.

Abstract Introduction Moral absolutism is the notion that “rights” and “wrongs” are independent of situational circumstances, it a core philosophy many religious traditions. We tested whether active church members Christian pastors showed resiliency to mild sleep restriction when reporting beliefs/cognitions, logging spiritual behaviors, judging deserved-punishments for moral mistakes. Methods ...

BACKGROUND Several genetic and environmental factors have been linked to Systemic Lupus Erythematosus (SLE). One environmental trigger that has a strong association with SLE is the Epstein Barr Virus (EBV). Our laboratory previously demonstrated that BALB/c mice expressing the complete EBNA-1 protein can develop antibodies to double stranded DNA (dsDNA). The present study was undertaken to unde...