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BACKGROUND The authors describe the preclinical pharmacological properties of GAL-021, a novel peripheral chemoreceptor modulator. METHODS The ventilatory effects of GAL-021 were characterized using tracheal pneumotachometry (n = 4 to 6), plethysmography (n = 5 to 6), arterial blood gas analyses (n = 6 to 11), and nasal capnography (n = 3 to 4) in naive animals and those subjected to morphine...
GAL-021 and GAL-160 are alkylamino triazine analogues, which stimulate ventilation in rodents, non-human primates and (for GAL-021) in humans. To probe the site and mechanism of action of GAL-021 and GAL-160 we utilized spirometry in urethane anesthetized rats subjected to acute bilateral carotid sinus nerve transection (CSNTX) or sham surgery. In addition, using patch clamp electrophysiology w...
At JLab, we have a unique opportunity to dramatically improve the F database. Much can be learned about the usefulness of QCD sum rules and relativistic potential models for understanding the structure of the pion in the (presumably) diicult and non-perturbative Q 2 regime of 1-5 (GeV=c) 2. This proposal deals with the continuation of our successful F program. Using the Hall C spectrometers and...
Results A total of 19 patients (11 M:8 F) had been found to carry the Del M694 variant. Clinical details were available on 16 patients who had been assessed at our centre. 13 were of white British ancestry, the other 3 were of Irish ancestry. 2 patients gave no relevant family history, 1 was adopted and unaware of any family details, 10 patients (from 5 kindreds) gave a history of similar sympt...
Qing Li 1,* , Xia Ji 1 and Steven Y. Liang 1,2 1 College of Mechanical Engineering, Donghua University, Shanghai 201620, China; [email protected] 2 George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0405, USA; [email protected] * Correspondence: [email protected] or [email protected]; Tel.: +86-021-6779-2583; Fax: +86-021-6779...
Dioxins are a group of anthropogenic chemical compounds created as unintended by-products through a number of activities including: combustion, certain types of chemical manufacture, chlorine bleaching of pulp and paper, and other industrial processes. Dioxins are produced in very small quantities compared to other pollutants; however, because this family of compounds are thought to be highly t...
Ascent sequences were introduced by Bousquet-Mélou, Claesson, Dukes and Kitaev in their study of (2 + 2)-free posets. An ascent sequence of length n is a nonnegative integer sequence x = x1x2 . . . xn such that x1 = 0 and xi ≤ asc(x1x2 . . . xi−1) + 1 for all 1 < i ≤ n, where asc(x1x2 . . . xi−1) is the number of ascents in the sequence x1x2 . . . xi−1. We let An stand for the set of such seque...
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