Correspondence: Marcus Tolentino Silva – Rod. Raposo Tavares, Km 92,5, Sorocaba-SP, CEP: 18023-000 E-mail: [email protected] Health economic evaluation studies are conducted in many different ways, depending on the health outcomes selected. In the present paper, we discuss the main types of outcomes used, presenting their characteristics, how to measure them and the scientific evidences that t...

Clarissa B. Oliveira, Ítalo R. T. Medeiros, Mario G. Greters, Norberto A. F. Frota, Leandro Tavares Lucato, Milberto Scaff, Adriana B. Conforto I AACD Adult Physiotherapy, São Paulo/SP, Brazil. II Hospital das Clı́nicas da Faculdade de Medicina da Universidade de São Paulo, Neurology, São Paulo/ SP, Brazil. III Hospital das Clı́nicas da Faculdade de Medicina da Universidade de São Paulo, Otorhino...

In urban centres of industrialising countries, the majority of houses are served by on-site sanitation systems such as septic tanks and unsewered toilets. The faecal sludges (FS) collected from these systems are usually discharged untreated into the urban and peri-urban environment, posing great risks to water resources and to public health. Contrary to wastewater management, the development of...

BACKGROUND Aroma, Spice, K2 and Dream are examples of a class of new and increasingly popular recreational drugs. Ostensibly branded "herbal incense", they have been intentionally adulterated with synthetic cannabinoids such as JWH-018 in order to confer on them cannabimimetic psychoactive properties while circumventing drug legislation. JWH-018 is a potent cannabinoid receptor agonist. Little ...

A single somatic mutation, V617F, in Janus kinase 2 (JAK2) is one of the causes of myeloproliferative neoplasms (MPNs), including primary myelofibrosis, and the JAK2V617F mutant kinase is a therapeutic target in MPN. However, inhibition of wild-type (WT) JAK2 can decrease the erythrocyte or platelet (PLT) count. Our selective JAK2 inhibitor, NS-018, suppressed the growth of Ba/F3 cells harborin...

Synthetic cannabinoid drugs do not cross react on traditional marijuana immunoassay tests, preventing their use in large scale drug screening programs. This paper describes the validation and performance characteristics of two enzyme linked immunosorbent assays designed to detect the use of two common synthetic cannabinoids in urine, JWH-018 and JWH-250. The JWH-018 assay has significant cross-...

scarce water resources is a worldwide problem, still for iran, a country predominated by an arid and semi-arid climate, water limitation is more severe than for many other areas of the world. a field experiment was conducted to investigate the impact of irrigation regimes on growth, grain yield and irrigation water use efficiency in maize (zea maize l.) in 2006 at the research farm, college of ...

BACKGROUND K2 products are synthetic cannabinoid-laced, marijuana-like drugs of abuse, use of which is often associated with clinical symptoms atypical of marijuana use, including hypertension, agitation, hallucinations, psychosis, seizures and panic attacks. JWH-018, a prevalent K2 synthetic cannabinoid, is structurally distinct from Δ(9)-THC, the main psychoactive ingredient in marijuana. Sin...

Synthetic cannabinoids JWH-018, JWH-073 and AM2201 were metabolised by the fungus Cunninghamella elegans. In this article, data on individual metabolites of their retention times, mass accuracies, major product ions and structures indicated by product ions are presented. The data in this article is related to "Biotransformation of synthetic cannabinoids JWH-018, JWH-073 and AM2201 by Cunningham...