mammalian CNS, the actions of which are regulated by ionotropic glutamate (iGlu) and metabotropic glutamate receptors (mGlu). mGlu receptors are a family of G-protein-coupled receptors comprising eight members, refered to as mGlu1-8. Group I receptors include mGlu1 and mGlu5, which when expressed are coupled via Gq to phospholipase C. Group II (mGlu2 and mGlu3) and group III (mGlu4,6,7,8) recep...

Positive allosteric modulators (PAMs) of a7 nicotinic acetylcholine receptors can enhance ion channel currents and downstream effects of a7 stimulation. We investigated the approach of using noncompetitive antagonists to regulate a7 receptor function, potentially distinguishing effects requiring ion channel currents from signaling induced by nonconducting states. Three small readily reversible ...

This study was designed to evaluate the in vivo activity of cytochrome P450 3A (CYP3A) in 49 healthy Japanese subjects aged 22–58 years using endogenous cortisol 6b-hydroxylation clearance [CLm(6b)], a novel biomarker for CYP3A phenotyping. CLm(6b) in the 49 healthy subjects was 2.40 6 0.79 ml/min with an approximately 4fold interindividual variability of CYP3A activity. The mean clearance in t...

S M T A s m s s n b p m m is now a postdoctoral research as Science and Engineering Departm University, and working to devel adhesives by integrating carbon na Center of Advanced Science and Engineerin of Macromolecular Science and Engineering, Reserve University, 10900 Euclid Avenue, Cle [email protected] Department of Materials Science and E University of North Texas, Denton, TX 7620 Cite this: Na...

The four large Swedish lakes Vänern, Vättern, Mälaren and Hjälmaren differ in many respects, not least in drainage area characteristics and basin morphometry (1). The differences also include water quality. Since nutrient chemistry of phosphorus (P) and nitrogen (N) in the lakes is of major concern, it has been treated by several authors (2–13). The hydrochemical studies started in 1964 and in ...

Exchange of macromolecules between the cytoplasm and the nucleus is mediated by dedicated transport channels in the nuclear envelope (NE) called nuclear pore complexes (NPCs). NPCs are embedded within NE at fusion sites between the inner and outer nuclear membrane. They are among the largest macro­ molecular assemblies in eukaryotic cells with an estimated mass of >50 MD (Hetzer et al., 2005; T...