Introduction The International Commission on Microbiological Specifications for Foods (ICMSF) has proposed a preventative scheme for managing microbial risks in foods that introduces the important new concept of a food safety objective (FSO). The FSO concept translates public health risk into a definable goal: a specified maximum frequency and/or concentration of a [microbiological] hazard in a...

The bioactive lipid sphingosine-1-phosphate (S1P) and its receptors (S1P1-5) play critical roles in many pathologic processes, including cancer. The S1P axis has become a bona fide therapeutic target in cancer. JTE-013 [N-​(2,​6-​dichloro-​4-​pyridinyl)-​2-​[1,​3-​dimethyl-​4-​(1-​methylethyl)-​1H-​pyrazolo[3,​4-​b]pyridin-​6-​yl]-​hydrazinecarboxamide], a known S1P2 antagonist, suffers from in...

Previously we demonstrated that sphingosine 1-phosphate receptor 1 (S1PR(1)) played a prominent, but not exclusive, role in enhancing the excitability of small-diameter sensory neurons, suggesting that other S1PRs can modulate neuronal excitability. To examine the potential role of S1PR(2) in regulating neuronal excitability we used the established selective antagonist of S1PR(2), JTE-013. Here...

Drugs that exhibit insurmountable antagonism are proposed to provide improved clinical efficacy through extended receptor blockade. Long-term suppression of the gonadotropin-releasing hormone receptor (GnRHR) is an important therapeutic approach for a number of sex hormone-dependent diseases. In this study, we describe the mechanism and structural components required for insurmountable activity...

aUniversité de Pau et des Pays de l’Adour LMAP UMR 5142 and Inria CAGIRE Team – Avenue de l’Université – 64 013 Pau, France bInria CAGIRE Team, Université de Pau et des Pays de l’Adour LMAP UMR 5142 – Avenue de l’Université – 64 013 Pau, France cCNRS, Université de Pau et des Pays de l’Adour LMAP UMR 5142 and Inria CAGIRE Team – Avenue de l’Université – 64 013 Pau, France dGhent University – De...

The suitability of individual MAb for application in vivo should be carefully confirmed. The monoclonal antibody GL-013, with specific binding reactivity in vitro to human tumors of the gastrointestinal tract, was radioiodinated and injected intraperitoneally into nude mice bearing human gastric carcinoma xenografts SY 86 B (moderately differentiated glandular adenocarcinoma) and SY 86 D (signe...