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Neutralizing the interaction of the platelet receptor gpIb with VWF is an attractive strategy to treat and prevent thrombotic complications. ALX-0081 is a bivalent Nanobody which specifically targets the gpIb-binding site of VWF and interacts avidly with VWF. Nanobodies are therapeutic proteins derived from naturally occurring heavy-chain-only Abs and combine a small molecular size with a high ...
[This corrects the article DOI: 10.1186/s40168-015-0081-x.].
1Pharmacology Department, Ablynx NV, Zwijnaarde, Belgium; 2Department of Interventional Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands; 3Department of Hematology and Cell Biology, University of Free State, Bloemfontein, South Africa; 4Department of Chemistry, Manufacturing and Controls, Ablynx NV, Zwijnaarde, Belgium; and 5Clinical Operations Department, Ablynx NV, Zwijnaarde, B...
Thrombolytic therapy is the cornerstone of treatment of acute atherothrombotic ischemic stroke but is associated with brain hemorrhage; antiplatelet therapy has limited efficacy and is still associated with intracranial bleeding. Therefore, new antithrombotic approaches with a better efficacy/safety ratio are required. We have assessed the effect of ALX-0081, a Nanobody against the A1 domain of...
*1 Japan Atomic Energy Research Institute, Tokai-mura, Naka-gun, Ibaraki 319-1195, Japan Email: [email protected] 2 National Institute for Materials Science, Sengen 1-2-1, Tsukuba-shi, Ibaraki 305-0047, Japan 3 Japan Science and Technology Corporation, Yonbancho 5-3, Chiyoda-ku, Tokyo 102-0081, Japan 4 Japan Nuclear Cycle Development Institute, Narita 4002, Oarai-machi, Ibaraki 311-...
Glucocorticoid-induced leucine zipper (GILZ) is a potent anti-inflammatory protein, the expression of which is mainly induced by glucocorticoids (GCs) in haematopoietic cells. GILZ regulates signal transduction pathways of inflammation and plays a role in cell survival. The objective of this study was to evaluate the expression and mechanisms of action of GILZ in the apoptosis of human neutroph...
Glucocorticoid-induced leucine zipper (GILZ) is a potent anti-inflammatory protein, the expression of which is mainly induced by glucocorticoids (GCs) in haematopoietic cells. GILZ regulates signal transduction pathways of inflammation and plays a role in cell survival. The objective of this study was to evaluate the expression and mechanisms of action of GILZ in the apoptosis of human neutroph...
Ryo Sugiura , Shogo Tsuda , Seiji Tamiya , Atsushi Itoh , Kentaro Nishiwaki , Noriyuki Murakami , Yukinori Shibuya , Masayuki Hirafuji , Stephen Nuske c a Hokkaido Agricultural Research Center, National Agriculture and Food Research Organization, 9-4 Shinseiminami, Memuro, Kasai, Hokkaido 082-0081, Japan b Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai...
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