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BACKGROUND/AIMS Increased osteoclast activity is a pivotal finding in osteoporosis. This increase is mediated via the mevalonate-to-cholesterol pathway, which is involved in producing the intermediates required for osteoclast activity. D-003, a mixture of high molecular weight sugarcane wax acids, has been shown to inhibit cholesterol synthesis prior to mevalonate production, resulting in a red...
BACKGROUND We evaluated the efficacy and safety of istradefylline, a selective adenosine A2A receptor antagonist administered as adjunctive treatment to levodopa for 12 weeks in a double-blind manner in Parkinson's disease patients with motor complications in Japan. METHODS A total of 373 subjects were randomized to receive placebo (n=126), istradefylline 20 mg/day (n=123), or istradefylline ...
Background: D-003 is a mixture of long-chain aliphatic primary acids purified from sugar cane wax with cholesterol-lowering and preventive effects on lipoprotein lipid peroxidation (LP) proven in experimental and clinical studies. Objectives: To investigate if D-003 favourably modifies LP markers on older individuals. Methods: This double-blinded, randomized, placebo-controlled study investigat...
In this individual patient data meta-analysis we examined datasets of two randomized placebo-controlled trials which investigated the effect nasal carrageenan separately on children and adults. both trials, iota-carrageenan was administered nasally three times per day for 7 days patients with common cold follow-up lasted 21 days. We used Cox regression to estimate recovery rate. also quantile c...
Two recently completed phase 3 trials (003 and 004) showed fidaxomicin to be noninferior to vancomycin for curing Clostridium difficile infection (CDI) and superior for reducing CDI recurrences. In both studies, adults with active CDI were randomized to receive blinded fidaxomicin 200 mg twice daily or vancomycin 125 mg 4 times a day for 10 days. Post hoc exploratory intent-to-treat (ITT) time-...
The use of anaerobic reactors for domestic sewage treatment has increased significantly since the UASB configuration started to be efficiently applied for this purpose in the beginning of the 1980s. Nowadays, hundreds of UASB reactors, or similar anaerobic units, are used in domestic sewage treatment systems, particularly in developing countries. These units have been operated at ambient temper...
and Applied Analysis 3 Table 1: Solitary wave Amp. 0.3 and the errors in L2 and L∞ norms for u, Q 1 , Q 2 , and Q 3 at t = 20, h = 0.125, Δt = 0.1, and −40 ≤ x ≤ 60. Method Time Q 1 Q 2 Q 3 L 2 for u L∞ for u Our method 0 3.9797 0.8104 2.5787 0 0 4 3.9797 0.8104 2.5786 3.6304e − 004 5.2892e − 005 8 3.9797 0.8104 2.5786 7.2873e − 004 5.8664e − 005 12 3.9797 0.8104 2.5787 1.0817e − 003 6.3283e − ...
A mathematical definit on of an information network is constructed with the purpose of developing a theory useful in answering practical questions concerning information transfer. An information network inCludes: (1) use,-s, (2) inf rmation resources, (3) information centers, and (4) the total information transfer structure linking (1), (2), and (3). Emphasis is placed on the message transfer s...
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