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In the present chapter we discuss methodologies for the modelling, calibration and validation of cellular signalling pathway dynamics. The discussion begins with the typical range of techniques for modelling that might be employed to go from the chemical kinetics to a mathematical model of biochemical pathways. In particular, we consider the decision making processes involved in selecting the r...

The present study was designed to test the effect of pravastatin, a new, 9hydroxy+methylglutaryl coenzyme A reductase inhibitor, on the progression of coronary artery disease in patients with moderate hypercholesterolemia. Angiographic eb try criteria included the presence of 21 stenosis 250% in a major epicardial coronary artery, and certiication of film quality through the core an@ography lab...

soon after cardiac transplantation, but the recipient patients seldom show a postoperative precordial murmur attributable to valve dysfunction. This is not surprising, because mild forms of valvular regurgitation detected by Doppler are often clinically inaudiblee5 Overt signs of tricuspid regurgitation and right ventricular failure were observed in 2 patients with residual postoperative pulmon...

Advances in technology and operator experience, and increased use of angiography early after myocardial infarction have led to greater use of percutaneous transluminal coronary angioplasty (PTCA) for chronic, total coronary artery occlusions. To better assess long-term outcome, 257 consecutive patients with successful PTCA of a total occlusion with late angiographic follow-up from 464 patients ...

Percutaneous cardiopulmonary bypass (PCB) was hmtttuted in 30 initially stable patients who developed either ctadiac arrest refractory to resuscitatton (n = 7) or cardiogenic shock (mean arts rial biood pressure cB0 mm Hg unresponsive to fluid resuscttation or vv) (n = 23) after a cation laboratory complication. Events leadhrg to collapse included abrupt closure during pe muaneous transkrminal ...