Li, Anlong, Adebowale Adebiyi, Charles W. Leffler, and Jonathan H. Jaggar. KCa channel insensitivity to Ca sparks underlies fractional uncoupling in newborn cerebral artery smooth muscle cells. Am J Physiol Heart Circ Physiol 291: H1118–H1125, 2006. First published April 7, 2006; doi:10.1152/ajpheart.01308.2005.—In smooth muscle cells, localized intracellular Ca transients, termed “Ca sparks,” ...

In smooth muscle cells, localized intracellular Ca2+ transients, termed "Ca2+ sparks," activate several large-conductance Ca2+-activated K+ (KCa) channels, resulting in a transient KCa current. In some smooth muscle cell types, a significant proportion of Ca2+ sparks do not activate KCa channels. The goal of this study was to explore mechanisms that underlie fractional Ca2+ spark-KCa channel co...

We previously found that 3,9-bis(N,N-dimethylcarbamoyloxy)-5H- benzofuro[3,2-c]quinoline-6-one (KCA-098) inhibited bone resorption in organ culture. In this study, to determine if KCA-098 is therapeutically applicable for the treatment of osteoporosis, we compared the effect of KCA-098 on bone tissues with that of ipriflavone, a drug that is clinically used for the treatment of osteoporosis. Bo...

Cheng, Xiaoyang, and Jonathan H. Jaggar. Genetic ablation of caveolin-1 modifies Ca spark coupling in murine arterial smooth muscle cells. Am J Physiol Heart Circ Physiol 290: H2309–H2319, 2006. First published January 20, 2006; doi:10.1152/ajpheart.01226.2005.—Ltype, voltage-dependent calcium (Ca ) channels, ryanodine-sensitive Ca release (RyR) channels, and large-conductance Ca activated pota...

An approach to Keystroke Continuous Authentication (KCA) is described founded on a time series analysis based approach that, unlike previous work on KCA (using feature vector representations) takes the sequencing of keystrokes into consideration. The significance of KCA is in the context of online assessments and examinations used in eLearning environments and MOOCs, which are becoming increasi...

The voltage- and Ca2+-activated, large conductance K+ channel (BK, maxi-K) is expressed in the collecting duct system of kidney where it underlies flow- and Ca2+-dependent K+ excretion. To determine if other Ca2+-activated K+ channels (KCa) may participate in this process, mouse kidney and the K+-secreting mouse cortical collecting duct (CCD) cell line, mCCDcl1, were assessed for TRPV4 and KCa ...

The hypothesis that protein kinase C (PKC) is able to regulate the whole cell Ca-activated K (KCa) current independently of PKC effects on local Ca release events was tested using the patch-clamp technique and freshly isolated rat tail artery smooth muscle cells dialyzed with a strongly buffered low-Ca solution. The active diacylglycerol analog 1,2-dioctanoyl- sn-glycerol (DOG) at 10 μM attenua...

Potassium channels govern duration and frequency of excitable membrane events and may regulate signals that are important in neuronal development. This study assesses the developmental expression of the large conductance Ca2+-dependent K+ channel in vivo and in vitro in rat cerebellum. In vivo, transcript levels for the Ca2+-dependent K+ channel (KCa) were shown by Northern analysis to increase...

Interactions of KCA-098 with heptakis(2,6-di-O-methyl)-beta-cyclodextrin (DM-beta-CyD) in solution and in the solid state were studied by the solubility method, UV and fluorescence spectroscopy, powder X-ray diffractometry, and thermal analysis. The KCA-098/DM-beta-CyD system showed an A(L) type solubility diagram with stability constants of 5870 and 2220 M(-1) in aqueous and 10% methanol solut...

Penelitian ini bertujuan untuk menguji pengaruh pendapatan, harga emas, dan jumlah nasabah terhadap pembiayaan Kredit Cepat Aman (KCA) PT. Pegadaian Cabang Kopang, Lombok Tengah pada masa pandemi COVID-19. Jenis penelitian yang digunakan adalah asosiatif dengan pendekatan kuantitatif. menggunakan data sekunder berupa pendapatan nasabah, penyaluran KCA COVID-19 periode 9 Maret 2020-31 Desember 2...