Dopamine replacement therapy for Parkinson’s disease is achieved using L-DOPA or dopamine D2/3 agonists, such as ropinirole. Here, we compare the effects of and ropinirole, alone in combination, on patterns glial microvascular reactivity striatum. Rats with unilateral 6-hydroxydopamine lesions were treated therapeutic-like doses (6 mg/kg), an equipotent L-DOPA-ropinirole combination (L-DOPA 3 m...

statement of problem: avulsion is one of the most serious emergencies in dental office. avulsed teeth should be stored in a medium that supports the periodontal ligament cells viability. in some clinical situations, preserving media, contained growth factors and mitogenic products may be used for repair of traumatized (periodontal ligament) tissues. it has been previously reported that levodopa...

avulsion is one of the most serious emergencies in dental office. in the event of any problem, the tooth should be stored in a medium that supports the periodontal ligament cell viability. in other clinical situations, preserving media, growth factors and mitogenic products may be useful in repairing the traumatized tissues. it has been previously reported that levodopa (l-dopa) accelerates hea...

Aim: Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons resulting in deterioration motor activity patients. Currently, available therapies including Levodopa (L-DOPA) are more geared toward treatment symptoms. Therefore, developing effective neuroprotective needed. Valproic acid (VPA) has shown potent effects on dopamine (DA) various brain regions. The aim...

l-Dopa@MSNs based on the concept of drug-structure-directing agents were successfully prepared and proved to be programmed oral l-Dopa release nanosystem pH responsive for treatment Parkinson's disease.

L-3,4-dihydroxyphenylalanine (L-dopa)-rich faba (Vicia L.) tissues are a potentially useful source for its pharmaceutical purpose, although the species contains health curious vicine and convicine in seeds. We determined contents of L-dopa, vicine, different plants throughout entire growth period. The three compounds accumulated germinating sprouts showed high at 8 days germination, especially ...

L-DOPA is therapeutically efficacious in patients with Parkinson's disease (PD), although dopamine (DA) neurons are severely degenerated. Since cortical astrocytes express neutral amino acid transporter (LAT) and DA transporter (DAT), the uptake and metabolism of L-DOPA and DA in striatal astrocytes may influence their availability in the dopaminergic system of PD. To assess possible L-DOPA- an...

Seven patients with Parkinsonism previously on l-dopa were placed on a regimen of l-dopa and alpha methyl dopa hydrazine (a dopa decarboxylase inhibitor). Two of these patients had previously shown marked clinical deterioration of the l-dopa improvement when given pyridoxine. None of the seven patients receiving alpha methyl dopa hydrazine demonstrated any change in their condition when given p...

In this study, undoped ZnO and doped with Fe and Mn nanostructures were synthesized by hydrothermal method. The morphology of nanostructures was characterized by Scanning Electron Microscope. The electrochemical response of the carbon paste electrode modified with nanoparticles of ZnO and also ZnO doped with Fe and Mn toward levodopa (L-Dopa) was studied. Studies of cyclic voltammetry using pro...

The noncoded aromatic 3,4-dihydroxy-L-phenylalanine (DOPA) amino acid has a pivotal role in the remarkable adhesive properties displayed by marine mussels. These properties have inspired the design of adhesive chemical entities through various synthetic approaches. DOPA-containing bioinspired polymers have a broad functional appeal beyond adhesion due to the diverse chemical interactions presen...