Subcutaneous injection is an important route of administration for therapeutic proteins that provides several advantages over other modes of parenteral delivery. Despite extensive clinical use, the exact mechanism underlying subcutaneous absorption of proteins is not completely understood, and the accuracy of prediction of absorption of biotherapeutics in humans remains unsatisfactory. This rev...

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Montelukast has been recommended as a selective in vitro and in vivo probe of cytochrome P450 (P450) CYP2C8 activity, but its selectivity toward this enzyme remains unclear. We performed detailed characterization of montelukast metabolism in vitro using human liver microsomes (HLMs), expressed P450s, and uridine 59-diphospho-glucuronosyltransferases (UGTs). Kinetic and inhibition experiments pe...

On Obsessions That Can Be Justified, or Racism the Polish WayReview of: Grzegorz Krzywiec, Szowinizm po polsku: Przypadek Romana Dmowskiego (1886–1905) [Chauvinism Way: The Case of Roman Dmowski (1886–1905)], Warszawa: Wydawnictwo Neriton, Instytut Historii PAN 2009. O obsesjach, które można uzasadnić, czyli rasizm polskuRecenzja: (1886–1905),