نتایج جستجو برای: 1367.

تعداد نتایج: 2031  

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه شهید بهشتی 1377
میرقاسم بنی هاشمی, امیرمحمد حاجی یوسفی,

هدف اساسی رساله بررسی این مسئله بود که ابزارها و شیوه های مشارکتی حمایتی که عمده ترین شیوه مشارکتی در دوره جنگ و قبل از آن بوده است . آیا توانسته اند مشارکت فعال و حتی حمایتی نیروهای اجتماعی را فراهم کنند. برای پاسخ به این سئوال ابتدا با توجه به مبانی نظری تحقیق، ابزارهای و شیوه های مشارکتی در جمهوری اسلامی را در دو گونه ابزارهای مستقیم و ابزارهای غیرمستقیم (سازمانی) مورد مطالعه قرار دادیم. انت...

15 صفحه اول
2014
Nelleke Snelder Bart A. Ploeger Olivier Luttringer Donald. R. Stanski Meindert Danhof

A complicating factor in the translational pharmacology of sphingosine 1-phosphate agonists is that they exert their pharmacological effect through their respective phosphate metabolites, which are formed by the enzyme sphingosine kinase (S1PHK). In this investigation, we present a semimechanistic pharmacokinetic model for the interconversion of S1PHK substrates and their respective phosphates ...

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Journal: :Revista Territórios e Fronteiras 2015

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2013
Harma Ellens Shibing Deng JoAnn Coleman Joe Bentz Mitchell E. Taub Isabelle Ragueneau-Majlessi Sophie P. Chung Krisztina Herédi-Szabó Sibylle Neuhoff Johan Palm Praveen Balimane Lei Zhang Masoud Jamei Imad Hanna Michael O’Connor Dallas Bednarczyk Malin Forsgard Xiaoyan Chu Christoph Funk Ailan Guo Kathleen M. Hillgren LiBin Li Anne Y. Pak Elke S. Perloff Ganesh Rajaraman Laurent Salphati Jan-Shiang Taur Dietmar Weitz Heleen M. Wortelboer Cindy Q. Xia Guangqing Xiao Tetsuo Yamagata Caroline A. Lee

In the 2012 Food and Drug Administration (FDA) draft guidance on drug-drug interactions (DDIs), a new molecular entity that inhibits Pglycoprotein (P-gp) may need a clinical DDI study with a P-gp substrate such as digoxin when themaximum concentration of inhibitor at steady state divided by IC50 ([I1]/IC50) is ‡0.1 or concentration of inhibitor based on highest approved dose dissolved in 250 ml...

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2005
Sun Shim Choi Weimin Li Bruce T Lahn

The structure of a protein depends critically on the complex interactions among its amino acid residues. It has long been hypothesized that interacting residues might tend to coevolve, but it is not known whether such coevolution is a general phenomenon across the proteome. Here, we describe a novel methodology called phylogeny-aided structural analysis, which uncovers robust signals of interac...

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2015
Alison J. Hugill Michelle E. Stewart Marianne A. Yon Fay Probert I. Jane Cox Tertius A. Hough Cheryl L. Scudamore Liz Bentley Gary Wall Sara E. Wells Roger D. Cox

Tryptophan metabolites have been linked in observational studies with type 2 diabetes, cognitive disorders, inflammation and immune system regulation. A rate-limiting enzyme in tryptophan conversion is arylformamidase (Afmid), and a double knockout of this gene and thymidine kinase (Tk) has been reported to cause renal failure and abnormal immune system regulation. In order to further investiga...

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Journal: :Proceedings of the International Astronomical Union 2007

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Journal: :Monthly Notices of the Royal Astronomical Society: Letters 2019

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2015
Satoru Hayano Yoshihiro Komatsu Haichun Pan Yuji Mishina

Bone morphogenetic protein (BMP) signaling plays many roles in skull morphogenesis. We have previously reported that enhanced BMP signaling through the BMP type IA receptor (BMPR1A) in cranial neural crest cells causes craniosynostosis during postnatal development. Additionally, we observed that 55% of Bmpr1a mutant mice show neonatal lethality characterized by a distended gastrointestinal trac...

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Journal: : 2021

Goal of the study – development and implementation provisions for further updating improvement components mechanism application Technical Regulations on type-approval agricultural or forestry tractors, their trailers interchangeable towed machinery, together with systems, separate technical units, approved by Resolution Cabinet Ministers Ukraine dated 28.12.2011 № 1367 (hereinafter Regulation 1...

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function paginate(evt) { url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term pg=parseInt(evt.target.text) var data={ "year":filter_year, "term":term, "pgn":pg } filtered_res=post_and_fetch(data,url) window.scrollTo(0,0); } function update_search_meta(search_meta) { meta_place=document.getElementById("search_meta_data") term=search_meta.term active_pgn=search_meta.pgn num_res=search_meta.num_res num_pages=search_meta.num_pages year=search_meta.year meta_place.dataset.term=term meta_place.dataset.page=active_pgn meta_place.dataset.num_res=num_res meta_place.dataset.num_pages=num_pages meta_place.dataset.year=year document.getElementById("num_result_place").innerHTML=num_res if (year !== "unfilter"){ document.getElementById("year_filter_label").style="display:inline;" document.getElementById("year_filter_place").innerHTML=year }else { document.getElementById("year_filter_label").style="display:none;" document.getElementById("year_filter_place").innerHTML="" } } function update_pagination() { search_meta_place=document.getElementById('search_meta_data') num_pages=search_meta_place.dataset.num_pages; active_pgn=parseInt(search_meta_place.dataset.page); document.getElementById("pgn-ul").innerHTML=""; pgn_html=""; for (i = 1; i <= num_pages; i++){ if (i===active_pgn){ actv="active" }else {actv=""} pgn_li="
  • " +i+ "
    • "; pgn_html+=pgn_li; } document.getElementById("pgn-ul").innerHTML=pgn_html var pgn_links = document.querySelectorAll('.mypgn'); pgn_links.forEach(function(pgn_link) { pgn_link.addEventListener('click', paginate) }) } function post_and_fetch(data,url) { showLoading() xhr = new XMLHttpRequest(); xhr.open('POST', url, true); xhr.setRequestHeader('Content-Type', 'application/json; charset=UTF-8'); xhr.onreadystatechange = function() { if (xhr.readyState === 4 && xhr.status === 200) { var resp = xhr.responseText; resp_json=JSON.parse(resp) resp_place = document.getElementById("search_result_div") resp_place.innerHTML = resp_json['results'] search_meta = resp_json['meta'] update_search_meta(search_meta) update_pagination() hideLoading() } }; xhr.send(JSON.stringify(data)); } function unfilter() { url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":"unfilter", "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } function deactivate_all_bars(){ var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(bar) { bar.dataset.active = false bar.style = "stroke:#71a3c5;" }) } year_chart.on("created", function() { var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(check) { check.addEventListener('click', checkIndex); }) }); function checkIndex(event) { var yrchart = document.querySelectorAll('.ct-bar'); var year_bar = event.target if (year_bar.dataset.active == "true") { unfilter_res = unfilter() year_bar.dataset.active = false year_bar.style = "stroke:#1d2b3699;" } else { deactivate_all_bars() year_bar.dataset.active = true year_bar.style = "stroke:#e56f6f;" filter_year = chart_data['labels'][Array.from(yrchart).indexOf(year_bar)] url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":filter_year, "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } } function showLoading() { document.getElementById("loading").style.display = "block"; setTimeout(hideLoading, 10000); // 10 seconds } function hideLoading() { document.getElementById("loading").style.display = "none"; } -->