With siRNA-based drugs becoming established as a therapeutic modality, large companies are engaging in the field through deals and acquisitions, cardiovascular metabolic diseases among their targets.

This paper examines the interaction of law and policy making on prostitution, with that of BDSM (bondage and discipline, sadism and masochism). Recent policy and legal shifts in the UK mark out prostitutes as vulnerable and in need of ‘rescue’. BDSM that amounts to actual bodily harm is unlawful in the UK, and calls to decriminalise it are often met with fears that participants will be left vul...

Pension buy-ins and buy-outs have become an important aspect of managing pension risk in recent years. As a step toward understanding these pension de-risking instruments, we develop models for pricing investment risk and longevity risk embedded in pension buy-ins and buy-outs. We also bring a contingent-claims framework to price credit risk of buy-in bulk annuities. Overall, our model can be u...

one of the ways of selling products is “direct selling”. the companies which use this method sell their products directly to end users just by their distributors’ intermediation. in this method, distributors retail sell the products out of a fixed commercial location. harmful effect of loading unsold products with distributors had legislators make companies buy-back those products. briefly, we ...