نتایج جستجو برای: ‘Phenylpiperazine’

تعداد نتایج: 174  

2017
Igor Konstantinov Konstantin Bukhryakov Yuri Mikhail Krasavin

A simple and practical method to prepare ‘libraries’ of substituted 1-phenylpiperazine building blocks in parallel format have been developed.

Journal: :Molecules 2010
Julien Laurent Dimitri Stanicki Tien L Huang Eduardo Dei-Cas Muriel Pottier El Mouktar Aliouat Jean Jacques Vanden Eynde

A library of 19 novel 4-(4-phenylpiperazine-1-yl)benzamidines has been synthesized and evaluated in vitro against Pneumocystis carinii. Among these compounds, N-ethyl- and N-hexyl-4-(4-phenylpiperazine-1-yl)benzamidines emerged as the most promising compounds, with inhibition percentages at 10.0 microg/mL of 87% and 96%, respectively. Those compounds remained active at 0.1 microg/mL.

Journal: :Pharmacological reports : PR 2011
Jacek Sapa Barbara Filipek Katarzyna Kulig Barbara Malawska

The present study was designed to investigate the central nervous system activity of 23 novel phenylpiperazine pyrrolidin-2-one derivatives. These compounds had marked antiarrhythmic and hypotensive activities and revealed affinity for α1- and α2-adrenoceptors. These effects may be related to their α-adrenolytic properties. We assessed their antidepressant-like effect in the forced swimming tes...

2012
Ivan Malík Marián Bukovský Fils Andriamainty Jana Gališinová

In the present investigation, the basic esters of meta-alkoxyphenylcarbamic acid bearing variously substituted N-phenylpiperazine fragment were screened for their in vitro antimicrobial activity against Staphylococcus aureus, Escherichia coli and Candida albicans, respectively. The most effective against Escherichia coli was found the compound 6d (MIC=195,3 μg/mL) bearing simultaneously para-fl...

Journal: :Acta Crystallographica Section E Structure Reports Online 2014

Journal: :Journal of Chemical Crystallography 2013

Journal: :Acta Crystallographica Section E Structure Reports Online 2010

2017
Moritz Schübler Bassem Sadek Tim Kottke Lilia Weizel Holger Stark

Neurleptic drugs, e.g., aripiprazole, targeting the dopamine D2S and D3 receptors (D2SR and D3R) in the central nervous system are widely used in the treatment of several psychotic and neurodegenerative diseases. Therefore, a new series of benzothiazole-based ligands (3-20) was synthesized by applying the bioisosteric approach derived from the selective D3Rs ligand BP-897 (1) and its structural...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید