The effects of grape seeds extract and grape peels extract prepared from grape pomace on the activity of antioxidant enzymes, degree of lipid peroxidation in serum and liver tissue were investigated in rabbits fed on high cholesterol diet. New Zealand white rabbits were divided as follows ; 1) NOR (normal group); 2) CHOL (cholesterol group); 3) GSH (cholesterol + grape seed extract group); 4) G...

Objectives: Cetuximab is an anticancerous drug which causes oral mucositis as a major side effect. Oral mucositis can be reduced by the effect of grape seed extract which modulates the inflammatory pathways. Our aim is to evaluate the effect of Grape seed extract and Cetuximab drug on mucositis and bacterial infection in tongue mucosa of experimental rats. Design: 24 rats were housed in the ani...

OBJECTIVE Mucositis is a serious disorder of the gastrointestinal tract that results from cancer chemotherapy. We investigated the effects of increasing grape seed extract doses on the severity of chemotherapy in a rat model and its coincident impact on chemotherapeutic effectiveness in colon cancer cells. DESIGN Female Dark Agouti rats were gavaged with grape seed extract (400-1000 mg/kg) or...

The skins and seeds of grapes are known to be rich sources of phenolic compounds, both flavonoids and non-flavonoids. The aim of the present study is to determine polyphenolic composition, antioxidant potential along with free radical scavenging activity and antimicrobial properties of ethanol extract of Grape skin and seed. Grape seed showed high antioxidant and antimicrobial activity compared...

INTRODUCTION Streptococcus mutans has been implicated as primary microorganisms which cause dental caries in humans. There has been an increased interest in the therapeutic properties of some medicinal plants and natural compounds which have demonstrated antibacterial activities. Grape is one of the plants of this group which contains tannin and polyphenolic compound. AIM To evaluate and comp...

background and aims. promoting remineralization is the ultimate goal of clinical prevention of caries lesion. the present in vitro study aimed to investigate the effect of grape seed extract (gse) on artificial enamel caries in primary human teeth. materials and methods. seventeen human sound primary incisors were sectioned mesiodistally. the tooth slices were placed in a demineralizing solutio...

thirty six wistar albino rats with implant induced endometriosis were randomly divided into six groups of six animals each. the rats in the first group received nothing and were euthanized at day 21. in the second group, rats received nothing and were euthanized at day 36. the third group received atorvastatin (atv; 5 mg kg-1 per day, orally) until 21 days from induction of endometriosis, and t...

BACKGROUND One of the known complications of diabetes mellitus is vascular dysfunction. Inability of the coronary vascular response to cardiac hyperactivity might cause a higher incidence of ischemic heart disease in diabetic subjects. It has been indicated that regular exercise training and antioxidants could prevent diabetic cardiovascular problems enhanced by vascular damage. OBJECTIVES Th...

conclusions in conclusion, taking gse for eight weeks had beneficial effects on the plasma gsh, mda levels, and markers of insulin metabolism of female volleyball players. results supplementation with gse resulted in a significant rise in the plasma glutathione (gsh) level (+265.5 ± 344.2 vs. +2.2 ± 378.2 µmol/l, p = 0.02), as well as a significant decrease in the malondialdehyde (mda) level (-...

Polyphenol-rich grape seed extract (0.1 w/w%) was incorporated in liposomes (1 w/w% soy lecithin) by high pressure homogenization (22,500 psi) and coated with chitosan (0.1 w/w%). Primary liposomes and chitosan-coated secondary liposomes containing grape seed extract showed good physical stability during 98 days of storage. Most of the polyphenols were incorporated in the shell of the liposomes...