نتایج جستجو برای: گیرنده HCA2

تعداد نتایج: 5935  

پوریا شعبانی .

گیرنده هیدروکسی کربوکسیلیک اسید2 ( HCA2 ) هدف داروی نیاسین است. در این مطالعه الگوی بیان این گیرنده ها در سلول های بخش های مختلف لوله گوارش (از دهان تا مری) موش صحرایی با روش ایمونوهیستوشیمی توصیف شده است. 6 موش صحرایی نر بالغ از نژاد ویستار تحت بیهوشی آسان کشی شدند. مقاطع بارافینی عرضی 5 میکرونی از مری، معده، دئودنوم، ژژونوم، ایلئوم، سکوم، کولون ها و رکتوم تهیه شد. آنتی بادی اولیه  جهت رنگ آمی...

Journal: :Journal of lipid research 2014
Kenneth R Feingold Arthur Moser Judy K Shigenaga Carl Grunfeld

Many of the beneficial and adverse effects of niacin are mediated via a G protein receptor, G protein-coupled receptor 109A/hydroxycarboxylic acid 2 receptor (GPR109A/HCA2), which is highly expressed in adipose tissue and macrophages. Here we demonstrate that immune activation increases GPR109A/HCA2 expression. Lipopolysaccharide (LPS), TNF, and interleukin (IL) 1 increase GPR109A/HCA2 expressi...

2017
Ying Shi Xiangru Lai Lingyan Ye Keqiang Chen Zheng Cao Wanghua Gong Lili Jin Chunyan Wang Mingyong Liu Yuan Liao Ji Ming Wang Naiming Zhou

The niacin receptor HCA2 is implicated in controlling inflammatory host responses with yet poorly understood mechanistic basis. We previously reported that HCA2 in A431 epithelial cells transduced Gβγ-protein kinase C- and Gβγ-metalloproteinase/EGFR-dependent MAPK/ERK signaling cascades. Here, we investigated the role of HCA2 in macrophage-mediated inflammation and the underlying mechanisms. We...

2014
Huawang Sun Guo Li Wenjuan Zhang Qi Zhou Yena Yu Ying Shi Stefan Offermanns Jianxin Lu Naiming Zhou

Niacin has been demonstrated to activate a PI3K/Akt signaling cascade to prevent brain damage after stroke and UV-induced skin damage; however, the underlying molecular mechanisms for HCA2-induced Akt activation remain to be elucidated. Using CHO-K1 cells stably expressing HCA2 and A431 cells, a human epidermoid cell line with high levels of endogenous expression of functional HCA2 receptors, w...

Journal: :The Plant cell 2009
Yong Guo Genji Qin Hongya Gu Li-Jia Qu

Vascular cambium, a type of lateral meristem, is the source of secondary xylem and secondary phloem, but little is known about the molecular mechanisms of its formation and development. Here, we report the characterization of an Arabidopsis thaliana gain-of-function mutant with dramatically increased cambial activity, designated high cambial activity2 (hca2). The hca2 mutant has no alternative ...

2014
Tahoora Shomali Najmeh Mosleh Mohammad Kamalpour

Interest in hydroxy - carboxylic acid 2 (HCA2) receptor has been raised since it is the target of antidyslipidemic drug nicotinic acid. The present study aimed to evaluate the presence of mRNA of this receptor in different organs of laboratory rat. Twenty two different organs of rats including mesenteric fat, epididymis (head, body and tail), testis, ovary, xiphoid process, liver, adrenal gland...

2012
Katsuyuki Ichitani Yuma Takemoto Kotaro Iiyama Satoru Taura Muneharu Sato

MANY POSTZYGOTIC REPRODUCTIVE BARRIER FORMS HAVE BEEN REPORTED IN PLANTS: hybrid weakness, hybrid necrosis, and hybrid chlorosis. In this study, linkage analysis of the genes causing hybrid chlorosis in F(2) generation in rice, HCA1 and HCA2, was performed. HCA1 and HCA2 are located respectively on the distal regions of the short arms of chromosomes 12 and 11. These regions are known to be high...

Journal: :Journal of Investigative Dermatology 2023

Gut commensal microbes affect the mucosal immune system via expansion of regulatory T cells (Treg) in colon. This is mediated short-chain fatty acids (SCFA), bacterial metabolites generated during fiber fermentation. SCFA are also produced by skin bacteria and may activate resident Treg, activity which diminished certain inflammatory dermatoses. Only upon binding to G-protein coupled receptors,...

حامدی, سمیه, شمالی, طهورا, معماریان مجرب, محمد,

زمینه و هدف: گیرنده HCA2 به‌عنوان هدف داروی مهم کاهنده لیپیدهای سرمی، یعنی نیاسین، بسیار موردتوجه است. این مطالعه به تعیین حضور و نیز شناسایی نوع سلول‌های بیان‌کننده این گیرنده در بافت‌های مختلف دستگاه ادراری موش صحرایی نر شامل کلیه، میزنای، مثانه و میزراه (در پنیس) می‌پردازد. روش بررسی: در این مطالعه تجربی از 6 سر موش صحرایی بالغ از نژاد Wistar استفاده شد. مقاطع بافتی از بخش‌های فوق‌الذکر تهیه...

2016
Tahoora Shomali Mohammad Kamalpour Mehdi Fazeli Alireza Rafati

The present study describes the changes in expression of hydroxy- carboxylic acid receptor 2 (HCA2 receptor) in femoral epiphysis and metaphysis of rats with glucocorticoid-induced osteoporosis (GIO). 16 growing male Sprauge dawley rats were randomly divided into two equal groups consisting of normal control and rats that were rendered osteoporotic by receiving 0.1 mg/kg/day dexamethasone subcu...

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