The intracellular pathogen Mycobacterium tuberculosis (Mtb) causes tuberculosis. Enhanced intracellular survival (Eis) protein, secreted by Mtb, enhances survival of Mycobacterium smegmatis (Msm) in macrophages. Mtb Eis was shown to suppress host immune defenses by negatively modulating autophagy, inflammation, and cell death through JNK-dependent inhibition of reactive oxygen species (ROS) gen...

Faradaic electrochemical impedance spectroscopy (f-EIS) in the presence of redox reagent, e.g., [Fe(CN)₆]3-/4-, is widely used in biosensors owing to its high sensitivity. However, in sensors detecting amyloid beta (Aβ), the redox reagent can cause the aggregation of Aβ, which is a disturbance factor in accurate detection. Here, we propose an interdigitated microelectrode (IME) based f-EIS tech...

Eis protein is reported to enhance the intracellular survival of Mycobacterium tuberculosis in human macrophages. Eis protein is not only known to skew away the immunity by disturbing the protective T(H)1 response, but aminoglycoside acetyltransferase activity of Eis is reported to regulate autophagy, inflammation and cell death. Here we have gained insight into the structure-function propertie...

In recent years a number of organisations have implemented executive information systems (EIS) in order to improve the performance of their executives’ jobs. Although the use of EIS is important in executives’ work, the majority of executives are unwilling to use EIS applications because of their design flaws. By using social factors, habits and facilitation condition variables from Triandis’ f...

Sargassum horneri is an edible marine brown alga distributed along the seacoast of Japan. Here we examined effects on the water-soluble (ethanol-insoluble) extracts (EIS) from Sargassum horneri on ion transports across the isolated rat colonic mucosa set in Ussing chambers. The nonpolysaccharide fraction of EIS (EIS-2) significantly decreased short-circuit current (Isc) across the mucosa, and i...

The Mycobacterium tuberculosis enhanced intracellular survival (Eis_Mtb) protein is a clinically important aminoglycoside (AG) multi-acetylating enzyme. Eis homologues are found in a variety of mycobacterial and non-mycobacterial species. Variation of the residues lining the AG-binding pocket and positions of the loops bearing these residues in the Eis homologues dictates the substrate specific...

There has been rapid growth in the number of implementations of Executive Information Systems (EIS). However the success rate of these systems has not been great. To minimize the risk of failed implementations, studies of theories and success factors for EIS implementation are recommended. This paper focuses on testing a model of successful EIS implementation and identifies success factors. An ...

Executive Information Systems (EIS) are designed to enhance the managerial roles of top-level managers in organizations. Despite reports of the growing popularity of EIS, there are reports of low usage of these systems that, in part, contributes to their failures in organizations. Majority of prior EIS research has focused on documenting the features, benefits, development methodologies, and im...

Recently, a framework to consider the overall architecture of enterprise information systems (EIS) such as the Enterprise Architecture (EA) has gained increasing popularity in Japan. In this paper, we propose a city planning approach for an EIS comprised of EIS architecture and an EIS Scenario. Our proposed approach leverages the methodology of city planning in civil engineering to provide a fr...