Background: Clonidine is used in critically ill patients for sedative and analgesic purposes. Objectives: 1) to review, systematically, the literature on prolonged intravenous (iv) clonidine for sedation in critically ill patients; 2) to evaluate the evidence from related fields of medicine on the use of clonidine for sedative or analgesic purposes, and; 3) to investigate prescribing practices ...

Background: Laparoscopy requires creation of a pneumoperitoneum which produces a significant rise in heart rate, mean arterial pressure, reduction in venous return and systemic vascular resistance. Various pharmacologic agents are used to control hemodynamic changes associated with pneumoperitoneum. Aim: To compare the effects of Clonidine administered intravenously (group IV) and intraperitone...

Administration (3 to 100 microg/kg IV) of clonidine, rilmenidine, and an imidazoline derivative, 2-(2-chlorophenylamino)imidazoline, in pithed nonstimulated rabbits caused a dose-dependent increase in mean arterial pressure without affecting heart rate. Prazosin (0.1 mg/kg IV) almost abolished the pressor responses to 2-(2-chlorophenylamino)imidazoline, partially inhibited those induced by clon...

UNLABELLED Although the mechanism of tourniquet-induced hypertension is still unclear, plasma norepinephrine concentrations continuously increase in parallel to arterial blood pressure during tourniquet inflation. Clonidine attenuates hyperadrenergic and hyperdynamic responses. We investigated the effects of clonidine on prolonged tourniquet inflation. Twenty-nine patients scheduled for electiv...

Clonidine is classified as a class 3 performance-enhancing agent by the Association of Racing Commissioners International and thus has the potential to influence the outcome of a race. In this study, the authors developed and validated a sensitive gas chromatograph and mass spectrometer method to determine the pharmacokinetic parameters of clonidine in equine plasma samples after IV administrat...

The use of dexmedetomidine with concurrent scalp block is increasingly being utilized as an effective and safe anesthetic approach for awake craniotomy (AC). Dexmedetomidine alpha-2 adrenergic receptor (α2-AR) agonist dose-dependent sedative, analgesic, anxiolytic properties while preserving respiratory function. challenge the arises when patient has a clonidine allergy, which also α2-AR agonis...

Background And Objectives: Laryngoscopy with or without tracheal intubation amounts to a highly noxious stimulus to the homeostasis of the patient. Many a times under lighter planes of anaesthesia it elicits a defence mechanism in the form of haemodynamic response to stress, which involves activation of adrenocortical system. This study was conducted to compare the effects of oral Clonidine and...