Pyke DA, Leslie RDG. Chlorpropamide-alcohol flushing: a definition of its relation to non-insulin-dependent diabetes. Br Med J 1978;ii: 1521-2. 2 Barnett AH, Pyke DA. Chlorpropamide-alcohol flushing and large-vessel disease in non-insulin-dependent diabetes. Br MedJ7 1980;281:261-2. 3 Jerntorp P, Almer L-O. Chlorpropamide-alcohol flushing in relation to macroangiopathy and peripheral neuropathy...

MILLER, M. & MOSES, A.M. (1969) Chlorpropamide induced release of antidiuretic hormone in patients with diabetes insipidus (abstracts). Clinical Research, 17, 290. MILLER, M. & MOSES, A.M. (1970a) Potentiation of vasopressin action by chlorpropamide in vivo. Endocrinology, 86, 1024. MILLER, M. & MOSES, A.M. (1970b) Mechanism of chlorpropamide in diabetes insipidus. Journal of Clinical Endocrino...

An epidemiological study was carried out to compare the prevalence of facial flushing in non-diabetics, patients with insulin dependent diabetes, and patients with non-insulin dependent diabetes in response to 40 ml sherry taken 12 hours after 250 mg chlorpropamide or placebo, administered double blind in randomised order. A flush after chlorpropamide but not placebo was reported by 6.2% of non...

To test the suggestion that chlorpropamide-alcohol flushing (CPAF) resembles the disulfiram effect and might be mediated by acetaldehyde, the initial metabolite of alcohol, blood concentrations of acetaldehyde were measured after a drink of alcohol in controls and diabetics positive and negative for CPAF. The CPAF-positive diabetics had significantly greater blood acetaldehyde concentrations af...

1. Chlorpropamide, carbamazepine and clofibrate have an antidiuretic action in patients with neurohypophyseal diabetes insipidus which is qualitatively similar to that of antidiuretic hormone (ADH). 2. An additive antidiuretic effect is produced by combination of chlorpropamide and carbamazepine with small dosages of ADH. 3. After an immediate and transient antidiuresis, a single intravenous bo...

THE ability of chlorpropamide to reduce urinary volume in patients with neurogenic diabetes insipidus has been recently described by Arduino, Ferraz & Rodriguez (1966), Meinders, Touber & De Vries (1967), Reforzo-Membrives et al. (1968), Hocken & Longson (1968), and Andreani, Cinotti & Stirati (1969). This therapy is potentially of great importance in the treatment of neurogenic diabetes insipi...

Sutherland, H. W., Bewsher, P. D., Cormack, J. D., Hughes, C. R. T., Reid, A., Russell, G., and Stowers, J. M. (1974). Archives of Disease in Childhood, 49, 283. Effect of moderate dosage of chlorpropamide in pregnancy on fetal outcome. The outcome of 19 pregnancies is reviewed in women receiving daily doses of at least 200 mg chlorpropamide for varying degrees of glucose intolerance. 4 require...

THE ability of chlorpropamide to reduce urinary volume in patients with neurogenic diabetes insipidus has been recently described by Arduino, Ferraz & Rodriguez (1966), Meinders, Touber & De Vries (1967), Reforzo-Membrives et al. (1968), Hocken & Longson (1968), and Andreani, Cinotti & Stirati (1969). This therapy is potentially of great importance in the treatment of neurogenic diabetes insipi...

The intravenous glucose tolerance test (I.V.G.T.T.) was used to diagnose chemical diabetes during pregnancy in 180 women, 50 of whom subsequently received chlorpropamide therapy in a daily dosage of 100 mg; the remainder had no drug therapy.Preliminary work showed the I.V.G.T.T. to be reproducible in the second and third trimesters but not in the puerperium in normal pregnancy. Though intraveno...