نتایج جستجو برای: کدون f31i
تعداد نتایج: 312 فیلتر نتایج به سال:
سابقه و هدف: مطالعات موجود درباره نقش سرطانزایی آلل هموزیگوتی و هترزیگوتی T/A کدون F31I ژن STK15 (Serine/ Threonine Kinase) در تومورهای مهاجم مجرایی سرطان پستان اطلاعات ضد و نقیضی ارایه می دهند. هدف این مطالعه مشخص کردن ژنوتیپ های F31I ژن STK15 در کارسینومای مهاجم مجرایی سرطان پستان در مقایسه با نمونه های کنترل در شهرستان سبزوار بوده است. مواد و روش ها: این مطالعه توصیفی تحلیلی بر روی 200...
سابقه و هدف: مطالعات موجود درباره نقش سرطانزایی آلل هموزیگوتی و هترزیگوتی t/a کدون f31i ژن stk15 (serine/ threonine kinase) در تومورهای مهاجم مجرایی سرطان پستان اطلاعات ضد و نقیضی ارایه می دهند. هدف این مطالعه مشخص کردن ژنوتیپ های f31i ژن stk15 در کارسینومای مهاجم مجرایی سرطان پستان در مقایسه با نمونه های کنترل در شهرستان سبزوار بوده است. مواد و روش ها: این مطالعه توصیفی تحلیلی بر روی 200...
Although few studies have suggested a carcinogenic role for polymorphism of F31I and V57I codons of AURKA gene in invasive ductal carcinoma, contradictory results from different populations mandates regional investigations. We aimed to determine polymorphisms of F31I and V57I codons of AURKA gene and their association with cancer prognosis in patients compared with controls in an eastern popula...
Several studies have identified the single nucleotide polymorphism STK15 F31I as a low-penetrance risk allele for breast cancer, but its prevalence and risk association in the Brazilian population have not been determined. The goal of this study was to identify the frequency of this polymorphism in the Brazilian setting. Considering the high degree of admixture of our population, it is of funda...
The AURKA oncogene is associated with abnormal chromosome segregation and aneuploidy and predisposition to cancer. Amplification of AURKA has been detected at higher frequency in tumors from BRCA1 and BRCA2 mutation carriers than in sporadic breast tumors, suggesting that overexpression of AURKA and inactivation of BRCA1 and BRCA2 cooperate during tumor development and progression. The F31I pol...
The association between the Serine/threonine kinase 15 (STK15) F31I polymorphism (rs2273535) and cancer susceptibility remains controversial. To further investigate this potential relationship, we conducted a comprehensive meta-analysis of 27 published studies involving a total of 19,267 multiple cancer cases and 24,359 controls. Our results indicate statistical evidence of an association betwe...
STK15 is considered a potential cancer susceptibility gene owing to its functions in normal cell mitosis. Two common coding region polymorphisms in the gene (F31I and V57I) may affect ubiquitin-dependent degradation and thus the half-life of the encoded protein. There are limited data on the relevance of these polymorphisms to population cancer rates. To examine whether functional variation in ...
STK15 may be a low-penetrance breast cancer susceptibility gene, and several reports suggest that women who are homozygous for the polymorphic variant F31I have an increased risk of breast cancer. To evaluate this potential breast cancer allele, we genotyped 507 patients with two primary breast cancers and 875 population-based control subjects for the STK15 F31I polymorphism. All statistical te...
STK15 is a putative oncogene that codes for a centrosome-associated, serine/threonine kinase, the normal function of which is to ensure accurate segregation of chromosomes during mitosis. Amplification of STK15 has been reported in ovarian tumors, suggesting a role in ovarian cancer pathology. STK15 is polymorphic with two single nucleotide substitutions (449t/a and 527g/a) in evolutionarily co...
PURPOSE To test the hypothesis that common sequence variants of cell cycle control genes may affect lung cancer predisposition. EXPERIMENTAL DESIGN We explored lung cancer risk associations of 11 polymorphisms in seven cell cycle genes in a large case-control study including 1,518 Caucasian lung cancer patients and 1,518 controls. RESULTS When individuals with variant-containing genotypes w...
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