نتایج جستجو برای: ژن stk15

تعداد نتایج: 15850  

ژورنال: فیض 2016
نمازی, محمد جواد , گل محمدی, رحیم,

سابقه و هدف: مطالعات موجود درباره نقش سرطان­زایی آلل هموزیگوتی و هترزیگوتی T/A کدون  F31I ژن STK15 (Serine/ Threonine Kinase) در تومورهای مهاجم مجرایی سرطان پستان اطلاعات ضد و نقیضی ارایه می­ دهند. هدف این مطالعه مشخص کردن ژنوتیپ­ های F31I ژن STK15 در کارسینومای مهاجم مجرایی سرطان پستان در مقایسه با نمونه­ های کنترل در شهرستان سبزوار بوده است. مواد و روش­ ها: این مطالعه توصیفی تحلیلی بر روی 200...

ژورنال: :فیض 0
رحیم گل محمدی rahman golmohammadi department of anatomy, faculty of medicine, sabzevar university of medical sciences, sabzevar, i. r. iran.سبزوار، دانشگاه علوم پزشکی سبزوار، دانشکده پزشکی، گروه علوم تشریحی محمد جواد نمازی mohammad javad namazi

سابقه و هدف: مطالعات موجود درباره نقش سرطان­زایی آلل هموزیگوتی و هترزیگوتی t/a کدون  f31i ژن stk15 (serine/ threonine kinase) در تومورهای مهاجم مجرایی سرطان پستان اطلاعات ضد و نقیضی ارایه می­ دهند. هدف این مطالعه مشخص کردن ژنوتیپ­ های f31i ژن stk15 در کارسینومای مهاجم مجرایی سرطان پستان در مقایسه با نمونه­ های کنترل در شهرستان سبزوار بوده است. مواد و روش­ ها: این مطالعه توصیفی تحلیلی بر روی 200...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2003
Donghui Li Jijiang Zhu Pervez F Firozi James L Abbruzzese Douglas B Evans Karen Cleary Helmut Friess Subrata Sen

PURPOSE Multiple chromosome abnormalities, including gain of chromosome20q, have been detected frequently in human pancreatic cancers. Overexpression of the STK15/BTAK/Aurora A gene located on chromosome 20q13, which encodes a centrosome-associated serine/threonine kinase, has been shown to induce chromosomal instability, leading to aneuploidy and cell transformation in multiple in vitro experi...

Journal: :International journal of oncology 2007
Stefan Denzinger Robert Stoehr Stephan Schwarz Nicole Eichenseher Gero Brockhoff Ellen C Obermann Ruth Knuechel Hagen Blaszyk Arndt Hartmann Peter J Wild

The aim of this study was to investigate STK15 amplification in histologically benign urothelium and invasive tumor tissue of urothelial bladder cancer patients in relation to clinicopathologic and molecular characteristics, and to analyze a hypothesized association between the STK15 single nucleotide polymorphism at site T91A (Phe31Ile) and STK15 gene amplification. A tissue microarray (TMA) w...

Journal: :Nucleic acids research 2002
Jian Du Gregory J Hannon

Alterations in the activity of the centrosomal kinase, Aurora-A/STK15, have been implicated in centrosome amplification, genome instability and cellular transformation. How STK15 participates in all of these processes remains largely mysterious. The activity of STK15 is regulated by phosphorylation and ubiquitin-mediated degradation, and physically interacts with protein phosphatase 1 (PP1) and...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2014
Guang-Lie Chen Gai-Ling Hou Fei Sun Hong-Li Jiang Jin-Feng Xue Xiu-Shen Li En-Hui Xu Wei-Shi Gao Jian-Ping Cao

BACKGROUND The STK15 gene located on chromosome 20q13.2 encodes a centrosome-associated kinase critical for regulated chromosome segregation and cytokinesis. Recent studies have demonstrated STK15 to be significantly associated with many tumors, with aberrant expression obseved in many human malignancies. The purpose of this study was to investigate expression of STK15 in esophageal squamous ce...

Journal: :Oncology reports 2007
Christine G Hammerschmied Robert Stoehr Bernhard Walter Wolf F Wieland Arndt Hartmann Hagen Blaszyk Stefan Denzinger

The search of inherited cancer susceptibility factors is an important subject in cancer epidemiology. Analyses of single nucleotide polymorphisms (SNP) in various genes revealed a correlation between the presence of specific allelic variants and cancer predisposition in diverse malignancies. STK15 is an important protein in control of the integrity of the mitotic spindle apparatus and genomic s...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004
Qi Dai Qiu-Yin Cai Xiao-Ou Shu Amanda Ewart-Toland Wan-Qing Wen Allan Balmain Yu-Tang Gao Wei Zheng

STK15 is a member of a family of serine/threonine kinases that act as key regulators of chromosome segregation and cytokinesis. Over expression of the STK15 gene leads to centrosome amplification, chromosomal instability, aneuploidy, and transformation. It has been reported that the 91T --> A (Phe --> Ile at codon 31) polymorphism in the STK15 gene affects the function of this gene. We hypothes...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2003
Ashraful Hoque Jennifer Carter Weiya Xia Mien-Chie Hung Aysegul A Sahin Subrata Sen Scott M Lippman

The biological mechanisms involved in the progression of ductal carcinoma in situ (DCIS) to invasive breast cancer are not fully understood. We previously have shown that the putative oncogene Aurora-A/STK15/BTAK, encoding a centrosome-associated kinase that regulates centrosomes and chromosome segregation, is amplified in human breast cancer. In this study, 37 archival breast tissue specimens ...

Journal: :The Journal of Cell Biology 2001
Akira Kawasaki Itaru Matsumura Jun-ichiro Miyagawa Sachiko Ezoe Hirokazu Tanaka Yasuhiko Terada Masaaki Tatsuka Takashi Machii Hiroshi Miyazaki Yusuke Furukawa Yuzuru Kanakura

During the late phase of megakaryopoiesis, megakaryocytes undergo polyploidization, which is characterized by DNA duplication without concomitant cell division. However, it remains unknown by which mechanisms this process occurs. AIM-1 and STK15 belong to the Aurora/increase-in-ploidy (Ipl)1 serine/threonine kinase family and play key roles in mitosis. In a human interleukin-3-dependent cell li...

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