نتایج جستجو برای: ژن itga4
تعداد نتایج: 15834 فیلتر نتایج به سال:
مقدمه: multiple sclerosis (ms) یک بیماری خود ایمنی مزمن سیستم عصبی مرکزی است که عوامل مختلف ژنتیک و محیطی در شیوع آن نقش دارند. با توجه به نقش استئوپونتین (opn یا osteopontin) و گیرنده ی آن (itga4 یا integrins alpha-4/beta-1) در پاسخ های ایمنی، ژن های کد کننده ی استئوپونتین و itga4 می توانند به عنوان عواملی جهت بررسی استعداد ابتلا به بیماری ms در نظر گرفته شوند. در مطالعه ی حاضر، فراوانی پلی مو...
The molecular mechanisms for the dissemination and metastasis of gastrointestinal stromal tumours (GIST) are incompletely understood. The purpose of the study was to investigate the clinical relevance of integrin alpha 4 (ITGA4) expression in GIST. GIST transcriptomes were first compared with transcriptomes of other types of cancer and histologically normal gastrointestinal tract tissue in the ...
Experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS), results from an autoimmune attack of the central nervous system (CNS) by effector T helper (Th) 1 and Th17 cells. Regulatory T cells (Treg) can control effector T cells and limit the progression of CNS autoimmunity. Integrin alpha 4 (Itga4) is critical for the entry of Th1 but not Th17 cells into the C...
UNLABELLED Although it is well established that BMP4 plays an important role in the development of hematopoietic system, it is less well understood whether BMP4 affects adult hematopoiesis and how. Here, we describe a novel mechanism by which BMP4 regulates homing of murine as well as human hematopoietic stem/progenitor cells (HSPCs). BMP4 treatment of murine BM derived c-kitLin-Sca-1 (KLS) and...
Human guanylate binding protein-1 (GBP-1) is a large GTPase that is induced by inflammatory cytokines and acts antiangiogenically through the inhibition of endothelial cell proliferation and migration. In this study, we detected that GBP-1-expressing cells show a significantly reduced spreading and migration on fibronectin matrices. Investigating possible mechanisms of these effects, we found t...
BACKGROUND Aberrantly methylated genes are promising biomarkers for the detection of colon adenomas and colorectal cancers (CRCs). The optimal assay type and specific methylated genes for these assays remain to be determined. METHODS We used genomewide microarray-based assays to identify methylated genes as candidate biomarkers for colon neoplasms. The frequency of aberrant methylation of the...
We recently mapped a quantitative trait locus for monocyte counts to chromosome 9q31 (rs7023923). Here we extend this work by showing with two independent approaches that rs7023923 regulates the expression levels of the nearby LPAR1 gene (P<0.0001), specifically implicating this gene in monocyte development. Furthermore, we tested 10 additional loci identified in the original analysis for repli...
Purpose: Colorectal cancer (CRC) screening method using stool DNA testing has shown greater detection rate than conventional fecal occult blood testing. The aim of this study was to determine the sensitivity and specificity of detection method using three promoter methylation markers of the ITGA4, SFRP2 and p16 for colorectal adenoma and carcinoma. Methods: The methylation status of the ITGA4, ...
جوجه های بومی جز مهم‌ترین ذخایر ژنتیکی هستند که به شرایط محیطی بخوبی سازگاری یافته‌اند. اما بطور معمول سرعت رشد و راندمان غذایی آنها در مقایسه با جوجه‌های امروزی مناسب است. مطالعات مقایسه‌ای بین جوجه‌های امروزی و مرغان بومی امکان درک علل این تفاوت‌های ژنتیکی را مهیا می‌سازد. جهت بررسی تفاوت‌های ترانسکریپتومی ژن‌ها و مسیرهای بیولوژیکی مرتبط با رشد ماهیچه سینه در دو گروه مرغ بومی و جوجه تجاری از ...
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