نتایج جستجو برای: ژن TSA1

تعداد نتایج: 15825  

Journal: :PLoS Genetics 2009
Ismail Iraqui Guy Kienda Jérémie Soeur Gérard Faye Giuseppe Baldacci Richard D. Kolodner Meng-Er Huang

Peroxiredoxins (Prxs) constitute a family of thiol-specific peroxidases that utilize cysteine (Cys) as the primary site of oxidation during the reduction of peroxides. To gain more insight into the physiological role of the five Prxs in budding yeast Saccharomyces cerevisiae, we performed a comparative study and found that Tsa1 was distinguished from the other Prxs in that by itself it played a...

Journal: :Journal of genetics and genomics = Yi chuan xue bao 2011
Wenjun Li Baisheng Zang Citao Liu Lu Lu Ning Wei Kaiming Cao Xing Wang Deng Xiping Wang

The COP9 signalosome (CSN) is a multiprotein complex which participates in diverse cellular and developmental processes. CSN1, one of the subunits of CSN, is essential for assembly of the multiprotein complex via PCI (proteasome, COP9 signalosome and initiation factor 3) domain in the C-terminal half of CSN1. However, the role of the N-terminal domain (NTD) of CSN1, which is critical for the fu...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2007
Sandrine Ragu Gérard Faye Ismail Iraqui Amélie Masurel-Heneman Richard D Kolodner Meng-Er Huang

The absence of Tsa1, a key peroxiredoxin that functions to scavenge H(2)O(2) in Saccharomyces cerevisiae, causes the accumulation of a broad spectrum of mutations including gross chromosomal rearrangements (GCRs). Deletion of TSA1 also causes synthetic lethality in combination with mutations in RAD6 and several key genes involved in DNA double-strand break repair. In the present study we invest...

اهمیت تغذیه‌ای گلوکوزینولات‌ها در انسان‌ها، حیوانات و اثرات آنها در بهبود سرطان، بیماری‌های قلبی-عروقی، عصبی و نقش دفاعی آنها درگیاهان علیه آفت‌ها و پاتوژن‌ها موجب گردیده است تا مسیر بیوسنتز گلوکوزینولات‌ها گزینه مناسبی جهت مطالعات ژنتیکی قرار گیرند. در شرایط تنشی، بیوسنتز گلوکوزینولات‌ها به‌وسیله مجموعه‌ای از فاکتورهای رونویسی تحت کنترل مثبت یا منفی قرار می‌گیرند. شبه رسپتورهای کینازی در واقع ...

ژورنال: شیمی آلی و پلیمر 2018

اهمیت تغذیه‌ای گلوکوزینولات‌ها در انسان‌ها، حیوانات و اثرات آنها در بهبود سرطان، بیماری‌های قلبی-عروقی، عصبی و نقش دفاعی آنها درگیاهان علیه آفت‌ها و پاتوژن‌ها موجب گردیده است تا مسیر بیوسنتز گلوکوزینولات‌ها گزینه مناسبی جهت مطالعات ژنتیکی قرار گیرند. در شرایط تنشی، بیوسنتز گلوکوزینولات‌ها به‌وسیله مجموعه‌ای از فاکتورهای رونویسی تحت کنترل مثبت یا منفی قرار می‌گیرند. شبه رسپتورهای کینازی در واقع ...

Journal: :The Biochemical journal 2008
Eleanor W Trotter Jonathan D Rand Jill Vickerstaff Chris M Grant

The yeast Tsa1 peroxiredoxin, like other 2-Cys peroxiredoxins, has dual activities as a peroxidase and as a molecular chaperone. Its peroxidase function predominates in lower-molecular-mass forms, whereas a super-chaperone form predominates in high-molecular-mass complexes. Loss of TSA1 results in aggregation of ribosomal proteins, indicating that Tsa1 functions to maintain the integrity of the...

Journal: :Cell 2016
Sarah Hanzén Katarina Vielfort Junsheng Yang Friederike Roger Veronica Andersson Sara Zamarbide-Forés Rebecca Andersson Lisa Malm Gael Palais Benoît Biteau Beidong Liu Michel B. Toledano Mikael Molin Thomas Nyström

Caloric restriction (CR) extends the lifespan of flies, worms, and yeast by counteracting age-related oxidation of H2O2-scavenging peroxiredoxins (Prxs). Here, we show that increased dosage of the major cytosolic Prx in yeast, Tsa1, extends lifespan in an Hsp70 chaperone-dependent and CR-independent manner without increasing H2O2 scavenging or genome stability. We found that Tsa1 and Hsp70 phys...

2016
Hayato Irokawa Tsuyoshi Tachibana Toshihiko Watanabe Yuka Matsuyama Hozumi Motohashi Ayako Ogasawara Kenta Iwai Akira Naganuma Shusuke Kuge

Peroxiredoxin is an abundant peroxidase, but its non-peroxidase function is also important. In this study, we discovered that Tsa1, a major peroxiredoxin of budding yeast cells, is required for the efficient flux of gluconeogenesis. We found that the suppression of pyruvate kinase (Pyk1) via the interaction with Tsa1 contributes in part to gluconeogenic enhancement. The physical interactions be...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2010
Theodora C Sideri Klement Stojanovski Mick F Tuite Chris M Grant

Peroxiredoxins (Prxs) are ubiquitous antioxidants that protect cells against oxidative stress. We show that the yeast Tsa1/Tsa2 Prxs colocalize to ribosomes and function to protect the Sup35 translation termination factor against oxidative stress-induced formation of its heritable [PSI(+)] prion conformation. In a tsa1 tsa2 [psi(-)] [PIN(+)] strain, the frequency of [PSI(+)] de novo formation i...

Journal: :Molecular biology of the cell 2006
Jonathan D Rand Chris M Grant

We previously showed that thioredoxins are required for dithiothreitol (DTT) tolerance, suggesting they maintain redox homeostasis in response to both oxidative and reductive stress conditions. In this present study, we screened the complete set of viable deletion strains in Saccharomyces cerevisiae for sensitivity to DTT to identify cell functions involved in resistance to reductive stress. We...

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