BACKGROUND Shear-induced platelet aggregation (SIPA) is an important mechanism in thrombogenesis. von Willebrand factor (vWF) binding to platelet glycoprotein Ib (GP Ib) has been found to be crucial for platelet aggregation under the high shear force probably generated in stenosed coronary artery. The physiological significance of vWF-dependent SIPA has not been clarified. METHODS AND RESULTS...

PURPOSE The utility of measuring the pediatric adjusted shock index (SIPA) at admission for predicting severity of blunt injury in pediatric patients has been previously reported. However, the utility of following SIPA after admission is not well described. METHODS The trauma registry from a level-one pediatric trauma center was queried from January 1, 2010 to December 31, 2015. Patients were...

BACKGROUND Type III secretion systems (TTSS) are employed by numerous pathogenic and symbiotic bacteria to inject a cocktail of different "effector proteins" into host cells. These effectors subvert host cell signaling to establish symbiosis or disease. METHODOLOGY/PRINCIPAL FINDINGS We have studied the injection of SipA and SptP, two effector proteins of the invasion-associated Salmonella ty...

Shear stress triggers von Willebrand factor (VWF) binding to platelet glycoprotein Ib and subsequent integrin IIb 3-dependent platelet aggregation. Concomitantly, nucleotides are released from plateletdense granules, and ADP is known to contribute to shear-induced platelet aggregation (SIPA). We found that the impaired SIPA of platelets from a HermanskyPudlak patient lacking dense granules was ...

BACKGROUND While the active participation of general practitioners (GPs) in integrated health services networks (IHSNs) plays a critical role in their success, little is known about the incentives and barriers to their actual participation. METHODS Data were gathered through semi-structured interviews and a mail survey with GPs enrolled in SIPA (system of integrated care for older persons) at...

Blood flow interacts with blood constituents and blood vessel under shear stress. Shear-induced platelet aggregation (SIPA) under high shear stress of stenosis has attracted research attention due to its involvement in vascular diseases, especially in life-threatening thrombosis. In SIPA, the calcium channel of platelet membrane can be activated by the interaction between plasma vWF and membran...

Shear stress triggers von Willebrand factor (VWF) binding to platelet glycoprotein Ibalpha and subsequent integrin alpha(IIb)beta(3)-dependent platelet aggregation. Concomitantly, nucleotides are released from plateletdense granules, and ADP is known to contribute to shear-induced platelet aggregation (SIPA). We found that the impaired SIPA of platelets from a Hermansky-Pudlak patient lacking d...