Background and aim: Dental caries is one of the most common childhood diseases worldwide. The implementation of strategies that facilitate the prevention of early dental caries and interrupt its progression has been recently advocated. It has been reported that casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) derived from casein reduces tooth demineralization and enhances the reminer...

The authors thank the referee for the constructive and helpful comments. Our detailed replies to the referee 2’s comments (in Italic) are given below. Anonymous Referee 2 This manuscript discusses an important topic, the contribution of ion-induced nucleation on atmospheric new particle formation. It is well-written, and in its current form, discreet, compared to the original manuscript. It is ...

As detailed below, we respect the work of Dr. Makarieva and co-authors (Makarieva et al., 2008), but we have come to similar conclusions as Dr. Haynes and decided not to accept the manuscript for final publication in ACP. The decision is supported by the entire ACP executive committee, but for clarity and simplicity the following editorial report is formulated from my perspective as the chief-e...

Two forms of spinach acyl carrier protein (ACP-I and ACP-II) have recently been characterized and found to be expressed in a tissue-specific manner (JB Ohlrogge, TM Kuo, 1985 J Biol Chem 260: 8032). To examine possible different functions for these ACP isoforms, we have tested purified preparations of spinach leaf ACP-I and ACP-II and Escherichia coli ACP in several in vitro reactions of fatty ...

The first condensation reaction in the fatty acid biosynthetic pathway in Escherichia coli was rate-limiting as judged by analysis of the relative pool sizes of acyl carrier protein (ACP) thioester intermediates in vivo. Comparable concentrations of acetyl-ACP, malonyl-ACP, and nonesterified ACP were present during logarithmic growth, whereas long-chain acyl-ACP comprised a minor fraction of th...

Acyl-malonyl acyl carrier protein (ACP)-condensing enzyme, prepared from extracts of Escherichia coli, catalyzes the condensation of acetyl-ACP and malonyl-ACP to form acetoacetyl-ACP. It also catalyzes the condensation of various longer chain saturated acyl-ACP derivatives with malonyl-ACP to form the P-ketoacyl-ACP of the longer homologues. The enzyme is specific for the acyl-ACP derivatives ...

OBJECTIVE Advance care planning (ACP) clarifies goals for future care if a patient becomes unable to communicate their own preferences. However, ACP uptake is low, with discussions often occurring late. This study assessed whether a systematic nurse-led ACP intervention increases ACP in patients with advanced respiratory disease. DESIGN A multicentre open-label randomised controlled trial wit...