Methods Blood samples were collected from 37 asthmatics patients and 60 unrelated normal individuals with informed consent. The DNA was isolated from PBL by using a salting out technique. SNPs were selected from dbSNP: http://www.ncbi.nlm.nih.gov/SNP/. Nine VDR polymorphisms were genotyped: FokI (rs2228570), Apal (rs7975232), BsmI (rs1544410), TaqI (rs731236), rs703842, rs4516035, rs 2248098, r...

OBJECTIVE To assess the association between coronary heart disease (CHD) and vitamin D receptor (VDR) gene polymorphisms in Han Chinese adults. METHODS A total of 215 CHD patients and 67 controls were recruited. In both groups, the VDR gene single nucleotide polymorphisms (SNP) of Tru9I (rs757343), ApaI (rs7975232), TaqI (rs731236) and FokI (rs2228570) were detected, and the frequencies of VD...

Background: Vitamin D receptor (VDR) is present on adipocytes, and many studies were performed to investigate the association between polymorphisms in VDR gene with obesity. However, in the Arab Gulf populations, whereas obesity prevalence is increasing dramatically, only a few studies were addressed this relation with obesity based only on body mass index. This study aimed to find the associat...

Background: Vitamin D receptor (VDR) is present on adipocytes, and many studies were performed to investigate the association between polymorphisms in VDR gene with obesity. However, in the Arab Gulf populations, whereas obesity prevalence is increasing dramatically, only a few studies were addressed this relation with obesity based only on body mass index. This study aimed to find the associat...

Purpose: The aim of study was to determine the relation vitamin D receptor gene (VDR) polymorphisms TaqI (rs731236), ApaI (rs7975232), BsmI (rs1544410), FokI (rs10735810) with risk obesity, metabolic syndrome and hepatosteatosis in children.Materials methods: 130 obese healthy children age range between 10-16 years included this study. Anthropometric measurements, biochemical evaluations abdomi...

Among the factors postulated to play a role in MS susceptibility, the role of vitamin D is outstanding. Since the function of vitamin D receptor (VDR) represents the effect of vitamin D on the body and genetic variations in VDR gene may affect its function, we aim to highlight the association of two VDR gene polymorphisms with MS susceptibility. In current study, we recruited 113 MS patients an...

Vitamin D is an important modulator of the immune response. It acts over several immune cell types where the Vitamin D receptor (VDR) is expressed. Due to the high relevance of this signaling pathway, several studies have investigated the possible influence of genes involved in the metabolism of Vitamin D and its receptor in different human diseases. Here, we analyzed whether four single-nucleo...

The vitamin D receptor (VDR) gene is a candidate gene for susceptibility to autoimmune disorders. Association studies of VDR polymorphisms and risk of type 1 diabetes often produced conflicting results in different ethnic backgrounds. The aim of this study was to test for association between common VDR polymorphisms and the genetic susceptibility to type 1 diabetes in the Portuguese population....

Aim: This study aimed to investigate the correlation between rates of coronavirus disease 2019 (COVID-19) prevalence and mortality frequency vitamin D receptor (VDR) gene polymorphisms at loci rs7975232 (ApaI), rs1544410 (BsmI), rs2228570 (FokI), rs731236 (TaqI) in cohorts from 26 countries.Methods: The included use countries where VDR (TaqI), (BsmI) were determined relevant frequencies alleles...