Abstract Background Transcription factors (TFs) may be engaged in reciprocal regulatory circuits with certain miRNAs to maintain cellular homeostasis. Disequilibrium of the reciprocities by tumor-related stimuli give rise deregulation downstream signaling pathways, thus promoting malignant tumor phenotypes. Specificity Protein 1 (SP1) is most representative member transcription factors. Previou...

This study explored morphological, mineralogical, and physicochemical features of suspected toxic mordenite fibers from Northern Italy. All the samples (FAS1, GC1, SP1) show similar structural chemical character, are Na-rich (Na > Ca K), Al content decrease reflects unit cell volumes in series: FAS1 SP1 GC1. The aerodynamic diameter (Dae) values 1.19 μm for GC1 sample, 2.69 FAS1, 3.91 SP1. s...

We study the computational complexity of two well-known graph transversal problems, namely Subset Feedback Vertex Set and Odd Cycle Transversal, by restricting input to H-free graphs, that is, graphs do not contain some fixed H as an induced subgraph. By combining known new results, we determine both problems on for every except when H=sP1+P4 s≥1. As part our approach, introduce Cover problem p...

We have shown that Sp1 phosphorylation at Thr739 decreases its DNA-binding activity. In this study, we found that phosphorylation of Sp1 at Thr739 alone is necessary, but not sufficient for the inhibition of its DNA-binding activity during mitosis. We demonstrated that Pin1 could be recruited to the Thr739(p)-Pro motif of Sp1 to modulate the interaction between phospho-Sp1 and CDK1, thereby fac...

PURPOSE Increasing evidence indicates that the transcription factor, Sp1, regulates the expression of multiple genes involved in tumor development and progression. We have recently reported that Sp1 overexpression is directly correlated with the angiogenic potential of and poor prognosis for human gastric cancer. However, the underlying mechanisms that result in Sp1 overexpression remain unclea...

BACKGROUND Specificity protein (Sp) 1 mediates the transcription of a large number of constitutive genes encoding physiological mediators. NF-κB mediates the expression of hundreds of inducible genes encoding pathological mediators. Crosstalk between Sp1 and NF-κB pathways could be pathophysiologically significant, but has not been studied. This study examined the crosstalk between the two path...

Transcription of luteinizing hormone receptor (LHR) gene is activated by Sp1/Sp3 at two Sp1 sites and is repressed by nuclear orphan receptors EAR2 and EAR3 through a direct-repeat (DR) motif. To elucidate the mechanism of the orphan receptor-mediated gene repression, we explored the functional connection between the orphan receptors and Sp1/Sp3 complex, and its impact on the basal transcriptio...