communities. Many communities and tribal governments have established research and ethics review boards to evaluate proposed projects in their communities, stemming from a growing awareness and sophistication of issues surrounding genetic and biomedical research, including individual versus community (or cultural) risk, adequacy of individual versus community consent issues, confidentiality, re...

• Then we could implement a model human, which, given input data comparable to what a human child gets, would acquire morphology and morphophonemics. It would generate new members of paradigms: “if [glEmp] is a verb, its past tense must be [glEmpt]” It would produce multiple responses and ambivalent judgments where people do: “past of [splIN] could be [spl√N], or [splINd], or perhaps even [splæ...

BRUCE is implicated in the regulation of DNA double-strand break response to preserve genome stability. It acts as a scaffold to tether USP8 and BRIT1, together they form a nuclear BRUCE-USP8-BRIT1 complex, where BRUCE holds K63-ubiquitinated BRIT1 from access to DSB in unstressed cells. Following DSB induction, BRUCE promotes USP8 mediated deubiquitination of BRIT1, a prerequisite for BRIT1 to...