The even–even and even–odd nuclei Xe-Xe and Ba-Ba are shown to have a wellrealized SO8 ⊃ SO6 ⊃ SO3 fermion dynamical symmetry. Their low-lying energy levels can be described by a unified analytical expression with two (three) adjustable parameters for even–odd (even–even) nuclei that is derived from the fermion dynamical symmetry model. Analytical expressions are given for wavefunctions and for...

The process of cellular iron uptake involves a specific receptor for the plasma carrier transferrin and a pathway of receptor-mediated endocytosis. Transferrin receptor expression is closely related to the rate of cell proliferation, and conjugates between anti-transferrin receptor monoclonal antibodies and toxins have been shown to have potent cytotoxic activity. We have constructed an anti-tr...

To develop a novel adjunctive therapy for CD30 (Ki-1)+ anaplastic large-cell lymphoma (ALCL), we investigated in preclinical studies the antitumor activity of an immunotoxin (IT) constructed by coupling the plant ribosome-inactivating protein saporin (SO6) to the monoclonal antibody (MoAb) Ber-H2 that is directed against the CD30 molecule, a new member of the tumor necrosis factor receptor (TNF...

We previously developed an antibody-avidin fusion protein (ch128.1Av) that targets the human transferrin receptor 1 (TfR1) and exhibits direct cytotoxicity against malignant B cells in an iron-dependent manner. ch128.1Av is also a delivery system and its conjugation with biotinylated saporin (b-SO6), a plant ribosome-inactivating toxin, results in a dramatic iron-independent cytotoxicity, both ...

We formulate a refined version of the global Gan–Gross–Prasad conjecture for general Bessel models, extending the work of Ichino–Ikeda and R. N. Harris in the co-rank 1 case. It is an explicit formula relating the automorphic period of Bessel type and the central value of certain L-function. To support such conjecture, we provide two examples for pairs SO5 SO2 and SO6 SO3 (both co-rank 3) in th...

We have previously developed an antibody fusion protein composed of a mouse/human chimeric IgG3 specific for the human transferrin receptor genetically fused to avidin (anti-hTfR IgG3-Av) as a universal delivery system for cancer therapy. This fusion protein efficiently delivers biotinylated FITC into cancer cells via TfR-mediated endocytosis. In addition, anti-hTfR IgG3-Av alone exhibits intri...

Synchronisation of replicated shared data is a key issue in collaborative writing systems. Most existing synchronization tools are specific to a particular type of shared data, i.e. text files, calendars, XML files. Therefore, users must use different tools to maintain their different copies up-to-date. In this paper we propose a generic synchronization framework based on the operational transf...

We have investigated the potentiation of transferrin [Tfn]-toxin [Tfn-ricin toxin A chain (RTA) and Tfn-So6 saporin toxin] and monoclonal antibody-RTA conjugates by monensin (Mo) and by a human serum albumin (HSA)-monensin conjugate in vitro. The in vivo survival and in vitro and in vivo toxicity of HSA-Mo were also studied; monensin was chemically linked to HSA carrier protein via a disulfide ...