نتایج جستجو برای: پروتئین نوترکیب tgf β1

تعداد نتایج: 52939  

TGFβ1 ، یک پروتئین تنظیمی چندکاره است که در طیف وسیعی از فعالیت‌های بیولوژیکی مداخله می‌نماید. این پروتئین، ابتدا به صورت یک فرم پیش ساز غیرفعال، حاوی 390 اسید آمینه سنتز می‌شود که قبل از اتصال به گیرنده‌های TGFβ1، تحت تاًثیر برش پروتئولیتیکی، فرم بالغ TGFβ1 از پروپپتید آن جدا می‌گردد. فرم بالغ این پروتئین شامل 112 اسید آمینه از انتهای C ترمینال فرم غیرفعال آن است. در این مطالعه، در ابتدا توانای...

Ali Akbar Pourfathollah Mohammad Hossein Karimi Saeed Daneshmandi

Background: Mesenchymal stem cells (MSCs) and transforming growth factor-β1 (TGF-β1) molecules are well known for their immunomodulatory properties and their function in tissue regeneration and remodeling. Objectives: To evaluate the interaction of TGF-β1 engineered MSCs with T cells and dendritic cells (DCs) and their modulatory effect on the immune response. Methods: MSCs and DCs were generat...

Journal: :iranian journal of allergy, asthma and immunology 0
sara hosseini-farahabadi jalil tavakkol-afshari rashin ganjali houshang rafatpanah javad ghaffari reza farid-hosseini

idiopathic chronic urticaria (icu), the most common form (70-80%) of chronic urticaria is supposed to have immune basis causes. it is speculated that the promoter polymorphism of tgf-β1 gene may be involved in icu. this condition is thought to affect at least 0.1% of the population and often can be severe and difficult to treat. a total of 40 patients with icu and 41 normal subjects were studie...

Background: Successful pregnancy in allopregnant women depends upon the control of graft rejection mechanisms. It has been suggested that some immunosuppressive cytokines contribute to successful pregnancy and transplantation. Transforming growth factor beta (TGF-   β) exhibits potent immunoregulatory and anti-inflammatory properties which might prolong graft survival. Recent studies suggest a ...

Journal: :iranian journal of immunology 0
maryam ayatollahi transplant research center alamtaj samsami dehaghani ob/gyn department, shiraz university of medical sciences, shiraz, iran ziaedin tabei transplant research center

background: successful pregnancy in allopregnant women depends upon the control of graft rejection mechanisms. it has been suggested that some immunosuppressive cytokines contribute to successful pregnancy and transplantation. transforming growth factor beta (tgf-   β) exhibits potent immunoregulatory and anti-inflammatory properties which might prolong graft survival. recent studies suggest a ...

Objective(s): To investigate and test the hypotheses that TGF-β1 enhanced myocardial differentiation through Wnt/β-catenin pathway with rat bone marrow mesenchymal stem cells (BMSCs).Materials and Methods: Lentiviral vectors carrying the TGF-β1 gene were transduced into rat BMSCs firstly. Then several kinds of experimental methods were u...

Journal: :iranian journal of radiation research 0
h. v. goutham department of radiation biology & toxicology, school of life sciences, manipal university, manipal, karnataka, india k. d. mumbrekar department of radiation biology & toxicology, school of life sciences, manipal university, manipal, karnataka, india n. hitendra department of biotechnology, school of life sciences, manipal university, manipal, karnataka india. b. m. vadhiraja department of radiation oncology, manipal hospital, bangalore, karnataka, india d. j. manipal university department of radiotherapy & oncology, shiridi saibaba cancer hospital and research centre, kasturba hospital, manipal, karnataka, india b. s. shiridi saibaba cancer hospital and research centre department of radiation biology & toxicology, school of life sciences, manipal university, manipal, karnataka, india

background: normal tissue toxicity continues to remain as a major challenge for radiation oncologists for delivering the total dose to the tumour cells in cancer patients. cellular, molecular and plasma based early biomarkers to predict the overreactions and non-overreactions of normal tissue toxicity before the initiation of radiotherapy can be valuable for personalised treatment. the aim of t...

Journal: :reports of biochemistry and molecular biology 0
mohammad reza khakzad tel: +98 9151176352; fax: +98 51- 32250048 farhad salari immunology research center, medical school, mashhad university of medical sciences, mashhad, iran maryam javanbakht department of psychiatrics, islamic azad university, mashhad branch, mashhad, iran maryam hojati noor hedayat center of autism spectrum disorders, mashhad, iran abdolreza varasteh allergy research center, mashhad university of medical sciences, mashhad, iran mojtaba sankian immunology research center, medical school, mashhad university of medical sciences, mashhad, iran

background: transforming growth factor-β1 (tgf-β1) has been found to play a crucial role in early central nervous system development. several studies have illustrated decreased tgf-β1 levels in sera and brains of autistic children. two point mutations in the tgf-β1 signal peptide at 869t/c and 915g/c have been reported to influence tgf-β1 expression. the aim of the present study was to investig...

ژورنال: پوست و زیبایی 2010
خواهشی, عیسی, شهرتی, مجید, فولادی ایمانی, عباسعلی, نورانی, محمدرضا, کشاورز, سعید,

Background and Aim: As a blistering agent, mustard gas causes a variety of disorders in different body organs, including the skin, such as altrations in DNA and clinical manifestations like pruritus. TGF-β1 molecule is a cytokine with anti-cell growth and inflammation suppression effects in skin inflammation. The aim of this study was to determine TGF-β1 gene exprtession in victims exposed to m...

Journal: :Applied sciences 2021

Background: Multiple studies have examined the potential of growth factors (GF) to enable mesenchymal stromal cells (MSC) nucleus pulposus (NP) cell-like cell differentiation. Here we screened a wide range GF and combinations for supporting NP Methods: Human MSC were stimulated using 86 different TGF-β1, -2, -3, GDF5, -6, Wnt3a, -5a, -11, Shh. Differentiation potency was assessed by alcian blue...

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