BACKGROUND For solid tumors, image cytometry has been shown to be more sensitive for diagnosing DNA content abnormalities (aneuploidy) than flow cytometry. Image cytometry has often been performed using the semi-automated CAS 200 system. Recently, an Automated Cellular Imaging System (ACIS) was introduced to determine DNA content (DNA index), but it has not been validated. METHODS Using the C...

The presence of occult bone marrow metastases (OM) has been reported to represent an important prognostic indicator for patients with operable breast cancer and other malignancies. Assaying for OM most commonly involves labor-intensive manual microscopic analysis. The present report examines the performance of a recently developed automated cellular image analysis system (ACIS; ChromaVision Med...

CONTEXT Certified athletic trainers who serve as Approved Clinical Instructors (ACIs) in the collegiate setting are balancing various roles (eg, patient care and related administrative tasks, clinical education). Whether this balancing act is associated with role strain in athletic trainers has not been examined. OBJECTIVE To examine the degree of, and contributing factors (eg, socialization ...

We examined United States Surveillance, Epidemiology, and End Results incidence data and conducted a population-based case-control study to examine the role of human papillomavirus (HPV) and oral contraceptive (OC) use in the etiology of adenocarcinoma in situ of the cervix (ACIS). One hundred and fifty women diagnosed with ACIS and 651 randomly selected control women completed in-person interv...

A post hoc analysis of the ATHENA study was performed to determine whether true HPV-negative cervical lesions occur and whether they have clinical relevance. The ATHENA database was searched for all CIN2 or worse (CIN2+) cases with cobas HPV-negative results and comparison was made with Linear Array (LA) and Amplicor to detect true false-negative HPV results. Immunostaining with p16 was perform...

To address the extreme dynamism and the rapidly changing user’s requirements in current information systems, an Autonomous Community Information System (ACIS) has been developed. ACIS is a decentralized architecture that forms a community of individual end-users (community members) having the same interests and demands at specified time and location. It admits them to mutually cooperate and sha...

ACIS observations of astronomical sources as well as its own external calibration source (ECS) have shown that molecular contamination has been building up on the optical/UV blocking filters since launch. Early LETG/ACIS observations of Ton S180 in Nov. 1999 and 3C 273 in Jan. 2000 showed that there was a slight reduction in the low energy ACIS QE1. A nearsimultaneous LETG/HRC-S observation of ...