Methodological aspects of multivariate statistical models to describe and to assess data from computer-analyzed corneal topographers (CACT) are considered. The data generated by repeated curvature mappings of calibrated steel balls are discussed in detail with the objective of formulating the basic questions and suggesting directions to assess data from clinical applications of CACT. The interp...

Insulin resistance (IR) and its health consequences (diabetes, hypertension, cardiovascular disease, obesity etc.) affect between 25 and 35% of Westernized populations. Decreased fatty acid (FA) oxidation in skeletal muscle is implicated in obesity-related IR. Carnitine-acylcarnitine translocase (CACT) transports long-chain FAs both into mitochondria (as carnitine esters for energy-generating p...

We previously demonstrated that micro-RNAs (miRNAs) 132 and 212 are differentially upregulated in response to obesity in two mouse strains that differ in their susceptibility to obesity-induced diabetes. Here we show the overexpression of miRNAs 132 and 212 enhances insulin secretion (IS) in response to glucose and other secretagogues including nonfuel stimuli. We determined that carnitine acyl...

Carnitine-acylcarnitine translocase (CACT) deficiency is one of the fatty acid oxidation defects that presents early in the newborn period. It is known to be associated with a high mortality with a number of the earlier reported cases presenting as sudden infant death syndrome. Like most inborn errors of metabolism, presentation of CACT deficiency is rather non specific. Typical biochemical pro...

The transport of solutes across the inner mitochondrial membrane is catalyzed by a family of nuclear-encoded membrane-embedded proteins called mitochondrial carriers (MCs). The citrate carrier (CiC) and the carnitine/acylcarnitine transporter (CACT) are two members of the MCs family involved in fatty acid metabolism. By conveying acetyl-coenzyme A, in the form of citrate, from the mitochondria ...

Neuropsychological deficits have been found to underlie the developmental disorders of various skills. Studies conducted thus far suggest education based remedial training (EBRT) to be beneficial in overcoming the developmental skill deficits. Though, computer assisted cognitive training (CACT) has been found to be effective in enhancing various cognitive functions in cases of traumatic brain i...

Dorsal-ventral patterning of the Drosophila embryo depends on NFκB superfamily transcription factor Dorsal (Dl). Toll receptor activation signals for degradation IκB inhibitor Cactus (Cact), leading to a ventral-to-dorsal nuclear Dl gradient. Cact is critical import, as it binds and prevents from entering nuclei. Quantitative analysis cact mutants revealed an additional function promote translo...

Graph invariants, based on the distances between the vertices of a graph, are widely used in theoretical chemistry. The degree resistance distance of a graph G is defined as D R (G) =  {u,v}⊆V (G) [d(u) + d(v)]R(u, v), where d(u) is the degree of the vertex u, and R(u, v) the resistance distance between the vertices u and v. Let Cact(n; t) be the set of all cacti possessing n vertices and t cy...