نتایج جستجو برای: پارومومایسین paromomycin

تعداد نتایج: 485  

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تهران 1347

چکیده ندارد.

Journal: :Antimicrobial agents and chemotherapy 2007
Go Hirokawa Hideko Kaji Akira Kaji

The effect of paromomycin on the interaction of ribosomal subunits was studied. Paromomycin inhibited the antiassociation activity of initiation factor 3 (IF3). Furthermore, ribosomal subunits were associated to form 70S ribosomes by paromomycin even in the presence of 1 mM Mg(2+). Paromomycin did not inhibit the binding of IF3 to the 30S ribosomal subunits. On the other hand, IF3 bound to the ...

Journal: :iranian journal of pharmaceutical research 0
m shahidi dadras a mirzaei b kazemi l nabai a sharifian

the current treatment of choice for cutaneous leishmaniasis is either parenteral or intralesional antimonial compounds. each of these treatments has its own downfalls which include toxic side effects with the parentral injection and pain at the site of injection with the intralesional injection. in recent years, there has been more focus on paromomycin as an alternative drug; however, current d...

Journal: :Journal of bacteriology 1989
J A Pérez-González M López-Cabrera J M Pardo A Jiménez

The mechanism conferring resistance to paromomycin in Streptomyces rimosus forma paromomycinus, the producing organism, was studied at the level of both protein synthesis and drug-inactivating enzymes. Ribosomes prepared from this organism grown in either production or nonproduction medium were fully sensitive to paromomycin. A paromomycin acetyltransferase and a paromomycin phosphotransferase,...

Journal: :The Indian journal of medical research 2008
C P Thakur

Paromomycin, an aminoglycoside, is known to cause several side effects like nephrotoxicity and ototoxicity like other aminoglycosides but tetany has not been reported. Three cases of tetany were detected in the patients of kala-azar treated with paromomycin. They were promptly treated with intravenous 10 per cent calcium gluconate and tetany was relieved immediately and treatment with paromomyc...

Journal: :The New England journal of medicine 2013
Afif Ben Salah Nathalie Ben Messaoud Evelyn Guedri Amor Zaatour Nissaf Ben Alaya Jihene Bettaieb Adel Gharbi Nabil Belhadj Hamida Aicha Boukthir Sadok Chlif Kidar Abdelhamid Zaher El Ahmadi Hechmi Louzir Mourad Mokni Gloria Morizot Pierre Buffet Philip L Smith Karen M Kopydlowski Mara Kreishman-Deitrick Kirsten S Smith Carl J Nielsen Diane R Ullman Jeanne A Norwood George D Thorne William F McCarthy Ryan C Adams Robert M Rice Douglas Tang Jonathan Berman Janet Ransom Alan J Magill Max Grogl

BACKGROUND There is a need for a simple and efficacious treatment for cutaneous leishmaniasis with an acceptable side-effect profile. METHODS We conducted a randomized, vehicle-controlled phase 3 trial of topical treatments containing 15% paromomycin, with and without 0.5% gentamicin, for cutaneous leishmaniasis caused by Leishmania major in Tunisia. We randomly assigned 375 patients with one...

Journal: :Antimicrobial agents and chemotherapy 2013
William R Ravis Alejandro Llanos-Cuentas Nestor Sosa Mara Kreishman-Deitrick Karen M Kopydlowski Carl Nielsen Kirsten S Smith Philip L Smith Janet H Ransom Yuh-Jing Lin Max Grogl

This study evaluated the pharmacokinetics of topical creams containing 15% paromomycin ("paromomycin alone") and 15% paromomycin plus 0.5% gentamicin (WR 279,396) in patients with cutaneous leishmaniasis. The investigational creams were applied topically to all lesions once daily for 20 days. Plasma samples were analyzed for simultaneous quantitation of paromomycin and gentamicin isomers and to...

Journal: :The Journal of antimicrobial chemotherapy 2014
Eliane de Morais-Teixeira Mariana Kolos Gallupo Lucas Fonseca Rodrigues Alvaro José Romanha Ana Rabello

OBJECTIVES To evaluate in vitro interactions between paromomycin sulphate and the antileishmanial drugs meglumine antimoniate, amphotericin B, miltefosine and azithromycin against intracellular Leishmania (Leishmania) infantum chagasi, Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis amastigotes in peritoneal mouse macrophages. METHODS First, drug susceptibility was a...

2013
Néstor Sosa Zeuz Capitán Javier Nieto Melissa Nieto José Calzada Hector Paz Carmenza Spadafora Mara Kreishman-Deitrick Karen Kopydlowski Diane Ullman William F. McCarthy Janet Ransom Jonathan Berman Charles Scott Max Grogl

In this randomized, double-blinded Phase 2 trial, 30 patients with Leishmania panamensis cutaneous leishmaniasis were randomly allocated (1:1) to receive once daily topical treatment with WR 279,396 (15% paromomycin + 0.5% gentamicin) or Paromomycin Alone (15% paromomycin) for 20 days. The index lesion cure rate after 6 months follow-up was 13 of 15 (87%) for WR 279,396 and 9 of 15 (60%) for Pa...

Journal: :The Journal of antimicrobial chemotherapy 2006
A Baishanbo G Gargala C Duclos A François J-F Rossignol J J Ballet L Favennec

OBJECTIVES To evaluate the efficacy of nitazoxanide and paromomycin in biliary tract cryptosporidiosis in an immunosuppressed Mongolian gerbil (Meriones unguiculatus) model. METHODS Gerbils (1-month-old) were dexamethasone-immunosuppressed for 10 days and challenged orally with 10(5) Cryptosporidium parvum oocysts. From day 0 to day 12 post-infection, one group (n=14) was treated with 200 mg/...

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