To elucidate the role of a type II transmembrane serine protease, ST14/Prss14, during breast cancer progression, we utilized publically accessible databases including TCGA, GEO, NCI-60, and CCLE. Survival of breast cancer patients with high ST14/Prss14 expression is significantly poor in estrogen receptor (ER) negative populations regardless of the ratios of ST14/Prss14 to its inhibitors, SPINT...

Suppressor of tumorigenicity 14 (St14) encodes matriptase, a serine protease, which regulates processing of profilaggrin to filaggin in vivo. Here, we report that transgenic mice with 1% of wild-type St14 levels (St14(hypo/-)) display aberrant processing of profilaggrin and model human ichthyotic skin phenotypes. Scaling of the skin appears at 1 week of age with underlying epidermal acanthosis ...

St14 is a type II transmembrane serine protease that contains a cytoplasm N-terminal domain, a stem domain, and a serine protease catalytic domain. It is primarily synthesized as an inactive zymogen and co-expressed with the cognate inhibitor hepatocyte growth factor inhibitor (HAI) in epithelial cells. Accumulating evidence suggests that it plays critical roles in pre-implant embryonic compact...

The fragile-X mental retardation syndrome, one of the most prevalent chromosome X-linked diseases (approximately equal to 1 of 2000 newborn males), is characterized by the presence in affected males and in a portion of carrier females of a fragile site at chromosomes band Xq27. We have performed a linkage analysis in 16 families between the locus for the fragile-X syndrome, FRAXQ27, and two pol...

Listeria monocytogenes is a food-borne pathogen able to survive and grow in different environments including food processing plants where it can persist for month or years. In the present study the discriminatory power of Whole Genome Sequencing (WGS)-based analysis (cgMLST) was compared to that of molecular typing methods on 34 L. monocytogenes isolates collected over one year in the same rabb...

ownloade kground: Matriptase plays a role in carcinogenesis, but the role of its genetic variation or that of the cyte growth factor activator inhibitor-1 (HAI-1) has not been evaluated. This study aimed to examine netic variation of matriptase (ST14 gene) and HAI-1 (SPINT1 gene) in breast cancer risk and prognosis, ess matriptase and HAI-1 gene and protein expression in breast tumors, and to i...

Naked foal syndrome (NFS) is a genodermatosis in the Akhal-Teke horse breed. We provide the first scientific description of this phenotype. Affected horses have almost no hair and show a mild ichthyosis. So far, all known NFS affected horses died between a few weeks and 3 yr of age. It is not clear whether a specific pathology caused the premature deaths. NFS is inherited as a monogenic autosom...

The serine proteases CAP1/Prss8 and CAP3/St14 are identified as ENaC channel-activating in vitro, highly suggesting that they required for proteolytic activation of vivo. present study tested whether is relevant renal affects ENaC-mediated Na+ absorption following deprivation conditions. knockout mice exhibit a significant decrease protein expression with altered subunit decreased pNCC abundanc...