► SiM would in future publish three issues per year; ► SiM would only accept papers that deal with fungal cultures, and/or fungal DNA, which should be deposited at CBS to be optimally accessible to the scientific community; ► SiM would publish papers by invitation or if a volume or special topic was supported by one of its associate editors; ► SiM would move to a print-on-demand system that all...

This paper proposes an extension of an SOM called the “SOM of SOMs,” or SOM, in which objects to be mapped are self-organizing maps. In SOM, each nodal unit of a conventional SOM is replaced by a function module of SOM. Therefore, SOM can be regarded as a variation of a modular network SOM (mnSOM). Since each child SOM module in SOM is trained to represent an individual map, the parent map in S...

The prosomatostatin-derived peptides somatostatin-14 (Som-14) and somatostatin-28 (Som-28) are believed to act as neurotransmitters in the central nervous system. To examine possible mechanisms by which these peptides induce their physiological actions in brain, the effects of Som-14 and Som-28 on voltage-dependent K+ currents in rat cerebral cortical neurons in culture were examined by using w...

A rational drug design approach involving transposition of functional groups from SRIF into a reduced size cyclohexapeptide template has led to the discovery of SOM230, a novel, stable cyclohexapeptide somatostatin mimic which exhibits unique high affinity binding to human somatostatin receptors (sst1-5). This unique receptor subtype binding profile, in particular the exceptional high affinity ...

The majority of cortical interneurons use GABA (gamma amino butyric acid) as inhibitory neurotransmitter. GABAergic neurons are morphologically, connectionally, electrically and chemically heterogeneous. In rat cerebral cortex three distinct groups of GABAergic interneurons have been identified by the expression of parvalbumin (PV), calretinin (CR) and somatostatin (SOM). Recent studies in mous...

Gastrin-releasing peptide (GRP) can stimulate both gastrin and somatostatin (SOM) secretion, but, as gastrin increases SOM and SOM in turn inhibits gastrin, the overall endpoint in terms of gastrin output is variable. To examine the mechanisms involved, we compared the effects of GRP on gastrin secretion in normal sheep and sheep chronically immunized against SOM. In the normal animal, GRP had ...