نتایج جستجو برای: نوروپاتی SYD

تعداد نتایج: 674  

ژورنال: علوم زیستی ورزشی 2017

  هدف از پژوهش حاضر بررسی تأثیر فعالیت ورزشی استقامتی بر بیان ژن SYD در نورون‌های حرکتی رت‌های مبتلا به نوروپاتی دیابت بود. بدین منظور، دوازده سر رت صحرایی بالغ نر نژاد ویستار به‌طور تصادفی در سه گروه چهارتایی دیابتی تمرین‌کرده (DT)، دیابتی تمرین‌نکرده (DC) و کنترل سالم (HC) قرار گرفتند. دو هفته پس از تزریق STZ برای القای دیابت، با اثبات نروپاتی دیابت توسط آزمون‌های رفتاری، پروتکل تمرین استقام...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Hidenori Taru Yishi Jin

Synapses are asymmetric structures that are specialized for neuronal signal transduction. A unique set of proteins is present at the presynaptic active zone, which is a core structure essential for neurotransmitter release. In Caenorhabditis elegans HSN neurons, SYD-2, a Liprin-α family protein, acts together with a GAP protein SYD-1 to promote presynaptic assembly. Previous studies have shown ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Ying Wang Elena O Gracheva Janet Richmond Taizo Kawano Jillian M Couto John A Calarco Vijhee Vijayaratnam Yishi Jin Mei Zhen

Communication between neurons is largely achieved through chemical synapses, where neurotransmitters are released from synaptic vesicles at presynaptic terminals to activate postsynaptic cells. Exo- and endocytosis are coordinated to replenish the synaptic vesicle pool for sustained neuronal activity. We identified syd-9 (syd, synapse defective), a gene that encodes multiple C2H2 zinc-finger do...

Journal: :Molecular and cellular neurosciences 2013
Poh Hui Chia Maulik R Patel Oliver I Wagner Dieter R Klopfenstein Kang Shen

SYD-2/liprin-α is a multi-domain protein that associates with and recruits multiple active zone molecules to form presynaptic specializations. Given SYD-2's critical role in synapse formation, its synaptogenic ability is likely tightly regulated. However, mechanisms that regulate SYD-2 function are poorly understood. In this study, we provide evidence that SYD-2's function may be regulated by i...

Journal: :The Journal of biological chemistry 2009
Namiko Abe Angels Almenar-Queralt Concepcion Lillo Zhouxin Shen Jean Lozach Steven P Briggs David S Williams Lawrence S B Goldstein Valeria Cavalli

The extreme polarized morphology of neurons poses a challenging problem for intracellular trafficking pathways. The distant synaptic terminals must communicate via axonal transport with the cell soma for neuronal survival, function, and repair. Multiple classes of organelles transported along axons may establish and maintain the polarized morphology of neurons, as well as control signaling and ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Scott Holbrook Jennifer K Finley Eric L Lyons Tory G Herman

Genetic analyses in both worm and fly have identified the RhoGAP-like protein Syd-1 as a key positive regulator of presynaptic assembly. In worm, loss of syd-1 can be fully rescued by overexpressing wild-type Liprin-α, suggesting that the primary function of Syd-1 in this process is to recruit Liprin-α. We show that loss of syd-1 from Drosophila R7 photoreceptors causes two morphological defect...

Journal: :The Journal of biological chemistry 2009
Kush Dalal Nham Nguyen Meriem Alami Jennifer Tan Trevor F Moraes Woo Cheol Lee Robert Maurus Stephen S Sligar Gary D Brayer Franck Duong

The Syd protein has been implicated in the Sec-dependent transport of polypeptides across the bacterial inner membrane. Using Nanodiscs, we here provide direct evidence that Syd binds the SecY complex, and we demonstrate that interaction involves the two electropositive and cytosolic loops of the SecY subunit. We solve the crystal structure of Syd and together with cysteine cross-link analysis,...

Journal: :Current Biology 2002
Doris Wagner Elliot M. Meyerowitz

BACKGROUND The plant-specific transcriptional activator LEAFY (LFY) is a central regulator of the transition to reproductive development in Arabidopsis. LFY has a second, later role in the induction of floral homeotic gene expression. Available data suggests that, while LFY activity is controlled via interaction with tissue-specific coactivators, other mechanisms exist that regulate LFY activit...

Journal: :The Journal of Cell Biology 2005
Valeria Cavalli Pekka Kujala Judith Klumperman Lawrence S.B. Goldstein

Neurons transmit long-range biochemical signals between cell bodies and distant axonal sites or termini. To test the hypothesis that signaling molecules are hitchhikers on axonal vesicles, we focused on the c-Jun NH2-terminal kinase (JNK) scaffolding protein Sunday Driver (syd), which has been proposed to link the molecular motor protein kinesin-1 to axonal vesicles. We found that syd and JNK3 ...

2004
Sushil K. Prasad Vijay K. Madisetti Shamkant B. Navathe Rajshekhar Sunderraman Erdogan Dogdu Anu G. Bourgeois Michael Weeks Bing Liu Janaka Balasooriya Arthi Hariharan Wanxia Xie Praveen Madiraju Srilaxmi Malladi Raghupathy Sivakumar Alex Zelikovsky Yanqing Zhang Yi Pan Saeid Belkasim

Currently, it is possible to develop a collaborative application running on a collection of heterogeneous, possibly mobile, devices, each potentially hosting data stores, using existing middleware technologies such as JXTA, BREW, compact .NET and J2ME. However, they require too many ad-hoc techniques as well as cumbersome and time-consuming programming. Our System on Mobile Devices (SyD) middle...

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