objective(s): the ability to measure cellular proliferation non-invasively in renal cell carcinoma may allow prediction of tumour aggressiveness and response to therapy. the aim of this study was to evaluate the uptake of 18ffluorothymidine (flt) pet in renal cell carcinoma (rcc), and to compare this to 18f-fluorodeoxyglucose (fdg), and to an immunohistochemical measure of cellular proliferatio...

Objective(s): The ability to measure cellular proliferation non-invasively in renal cell carcinoma may allow prediction of tumour aggressiveness and response to therapy. The aim of this study was to evaluate the uptake of 18Ffluorothymidine (FLT) PET in renal cell carcinoma (RCC), and to compare this to 18F-fluorodeoxyglucose (FDG), and to an immunohistochemical measure of cellular proliferatio...

Vascular endothelial growth factor and its receptors, including Flt-1 and Flk-1, are involved in angiogenesis under physiologic and pathologic conditions. Recently, Flt-1-expressing cells were reported to contribute to the intracranial growth of glioma cells. However, the role of Flt-1 signaling in solid tumor growth in s.c. tissue has not been elucidated. To investigate how Flt-1 signaling is ...

Recently, we have reported a series of isatin hydrazone, two them, namely, 3-((2,6-dichlorobenzylidene)hydrazono)indolin-2-one (1) and 3-((2-chloro-6-fluorobenzylidene)hydrazono)indolin-2-one (2) having potent cytotoxicity, showing cyclin-dependent kinases (CDK2) inhibitory activity bearing recommended drug likeness properties. Since both compounds (1 2) showed against CDK2, assumed it would al...

PURPOSE Experimental studies have revealed that fms-like tyrosine kinase (Flt)-4 plays important roles in lymphangiogenesis in malignant tumors, but the clinical significance remains unclear. We assessed Flt-4 expression in tumor cells and in endothelial cells in correlation with clinical outcomes in non-small cell lung cancer (NSCLC). EXPERIMENTAL DESIGN A total of 206 consecutive patients w...

Download cular endothelial growth factor and its receptors, including Flt-1 and Flk-1, are involved in angiogenesis physiologic and pathologic conditions. Recently, Flt-1–expressing cells were reported to contribute to racranial growth of glioma cells. However, the role of Flt-1 signaling in solid tumor growth in s.c. tissue t been elucidated. To investigate how Flt-1 signaling is involved in t...

nloaded cular endothelial growth factor and its receptors, including Flt-1 and Flk-1, are involved in angiogenesis physiologic and pathologic conditions. Recently, Flt-1–expressing cells were reported to contribute to racranial growth of glioma cells. However, the role of Flt-1 signaling in solid tumor growth in s.c. tissue t been elucidated. To investigate how Flt-1 signaling is involved in th...

Mice lacking the vascular endothelial growth factor (VEGF) receptor flt-1 (VEGFR-1) die from vascular overgrowth, caused primarily by aberrant endothelial cell division (Kearney JB, Ambler CA, Monaco KA, Johnson N, Rapoport RG, Bautch VL: Vascular endothelial growth factor receptor Flt-1 negatively regulates developmental blood vessel formation by modulating endothelial cell division. Blood 200...

PURPOSE The objective of this research was to formulate flutamide (FLT) in hydroxypropyl-beta-cyclodextrin (HPbetaCyD), and to investigate FLT transcellular permeation from the complex using the Caco-2 monolayer in vitro model. METHODS Classical solubility data were used to derive thermodynamic parameters which, together with Differential Scanning Calorimetry (DSC), (1)H-NMR and (19)F-NMR, we...