نتایج جستجو برای: ناقل glt1

تعداد نتایج: 1642  

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه علوم پایه دامغان - دانشکده علوم پایه دامغان 1394

مقدمه: هایپرآمونیا سمیت زیادی بر روی سیستم عصبی مرکزی دارد و موجب تشنج یا کما می شود. در این مطالعه اثر هایپرآمونیا بر روی بیان ناقل گلوتامات (glt1)، فعالیت آنزیم گلوتامین سینتتاز(gs) و آنزیم های آنتی اکسیدانتی (sod,gpx)و هم چنین اثر محافظتی یوژنول در مقابل سمیت ناشی از هایپرآمونیا در هیپوکمپ موش های صحرایی بررسی شد. مواد و روش ها: موش های نر بالغ با وزن 250-220 گرم به چهار گروه کنترل (تزریق...

Journal: :Journal of bacteriology 1998
L Valenzuela P Ballario C Aranda P Filetici A González

Saccharomyces cerevisiae glutamate synthase (GOGAT) is an oligomeric enzyme composed of three 199-kDa identical subunits encoded by GLT1. In this work, we analyzed GLT1 transcriptional regulation. GLT1-lacZ fusions were prepared and GLT1 expression was determined in a GDH1 wild-type strain and in a gdh1 mutant derivative grown in the presence of various nitrogen sources. Null mutants impaired i...

Journal: :Glia 2010
Yongjie Yang Oguz Gozen Svetlana Vidensky Michael B Robinson Jeffrey D Rothstein

Astroglial glutamate transporter EAAT2/GLT1 prevents glutamate-induced excitotoxicity in the central nervous system. Expression of EAAT2/GLT1 is dynamically regulated by neurons. The pathogenesis of amyotrophic lateral sclerosis (ALS) involves astroglial dysfunction, including dramatic loss of EAAT2/GLT1. DNA methylation of gene promoters represents one of the most important epigenetic mechanis...

2017
Jacqueline A. Hubbard Devin K. Binder

The accumulation of glutamate in the brain is toxic to neurons and therefore must be tightly regulated. Expressed predominantly on astrocytes, glutamate transporter-1 (GLT1) is responsible for the majority of glutamate clearance from the extracellular space in the forebrain (Figure 1). Due to its importance in glutamate homeostasis and consequently maintaining neuronal health, dysregulation of ...

Journal: :The Journal of biological chemistry 2011
Alice Y C Liu Rohan Mathur Newton Mei Christopher G Langhammer Bruce Babiarz Bonnie L Firestein

Heat shock factor 1 (HSF1) mediates the cellular response to stress to increase the production of heat shock protein (HSP) chaperones for proper protein folding, trafficking, and degradation; failure of this homeostatic mechanism likely contributes to neurodegeneration. We show that the neuroprotective drug riluzole increased the amount of HSF1 in NG108-15 neuroprogenitor cells by slowing the s...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Kathryn D Fischer Alexander C W Houston George V Rebec

Relapse to cocaine-seeking behavior requires an increase in nucleus accumbens (NAc) core glutamate transmission. Decreased expression of glutamate type I transporter (GLT1), which is responsible for >90% of glutamate clearance, occurs in the core of rats withdrawn from cocaine self-administration, while treatment with ceftriaxone, a β-lactam antibiotic previously shown to increase GLT1 expressi...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
Ke Li Charles Nicaise Daniel Sannie Tamara J Hala Elham Javed Jessica L Parker Rajarshi Putatunda Kathleen A Regan Valérie Suain Jean-Pierre Brion Fred Rhoderick Megan C Wright David J Poulsen Angelo C Lepore

A major portion of spinal cord injury (SCI) cases affect midcervical levels, the location of the phrenic motor neuron (PhMN) pool that innervates the diaphragm. While initial trauma is uncontrollable, a valuable opportunity exists in the hours to days following SCI for preventing PhMN loss and consequent respiratory dysfunction that occurs during secondary degeneration. One of the primary cause...

2017
Jacqueline A. Hubbard Devin K. Binder

Maintenance of glutamate and water homeostasis in the brain is crucial to healthy brain activity. Astrocytic glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4) are the main regulators of extracellular glutamate and osmolarity, respectively. Several studies have reported colocalization of GLT1 and AQP4, but the existence of a physical interaction between the two has not been well studied. The...

Journal: :Human molecular genetics 2013
Haruki Higashimori Lydie Morel James Huth Lothar Lindemann Chris Dulla Amaro Taylor Mike Freeman Yongjie Yang

Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by the loss-of-function of fragile X mental retardation protein (FMRP). The loss of FMRP function in neurons abolishes its suppression on mGluR1/5-dependent dendritic protein translation, enhancing mGluR1/5-dependent synaptic plasticity and other disease phenotypes in FXS. In this study, we describe a new activation function of FM...

Journal: :American journal of physiology. Renal physiology 2016
A Lenore Ackerman Forrest C Jellison Una J Lee Sylvie Bradesi Larissa V Rodríguez

Psychological stress exacerbates interstitial cystitis/bladder pain syndrome (IC/BPS), a lower urinary tract pain disorder characterized by increased urinary frequency and bladder pain. Glutamate (Glu) is the primary excitatory neurotransmitter modulating nociceptive networks. Glt1, an astrocytic transporter responsible for Glu clearance, is critical in pain signaling termination. We sought to ...

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