Widespread resistance towards antimony and reports of relapses following miltefosine treatment has severely affected the management of visceral leishmaniasis (VL) in the Indian subcontinent. Paromomycin (PMM), an aminoglycoside antibiotic, has been licensed for VL treatment in India in 2007. Although its use is still restricted in the field, unraveling the molecular mechanism of resistance towa...

In recent years, performance measurement and management (PMM) has received much attention from researchers and practitioners. Despite the growing use of PMM systems, different problems cause companies to experience difficulty in implementing such systems, with consequent risk of partial benefits or total goal failure. The literature on PMM is nowadays quite vast, but only a ten of models addres...

The paper reviews the literature in the field of performance measurement and management (PMM) for small and medium enterprises (SMEs) and it proposes a framework for PMM system design. The results of the literature review carried out reveal the need for developing real integrated PMM frameworks. Based on such a structured literature review, we propose an integrated framework that rectifies the ...

Software development processes such as the Waterfall process and Extreme Programming are Project Management Methods (PMMs) which are well known and widely used. However, conventional Project Management (PM) lacks the process concepts expressed in PMMs, and the connection between PMMs and PM is not much explored in the literature. Our research problem is to make this connection. We present data ...

We have previously shown that histone H3 is transiently phosphorylated at Thr3 during mitosis. Extending these studies, we now report that phosphorylated Thr3 is always in cis to trimethylated Lys4 and dimethylated Arg8, forming a new type of combinatorial modification, which we have termed PMM. PMM-marked chromatin emerges at multiple, peripheral sites of the prophase nucleus, then forms disti...

Hybrid molecular dynamics (MD) simulations, in which the forces acting on the atoms are calculated by grid-based density functional theory (DFT) for a solute molecule and by a polarizable molecular mechanics (PMM) force field for a large solvent environment composed of several 10(3)-10(5) molecules, pose a challenge. A corresponding computational approach should guarantee energy conservation, e...

Leishmania donovani is the causative agent of the potentially fatal disease visceral leishmaniasis (VL). Chemotherapeutic options available to treat VL are limited and often face parasite resistance, inconsistent efficacy, and toxic side effects. Paromomycin (PMM) was recently introduced to treat VL as a monotherapy and in combination therapy. It is vital to understand the mechanisms of PMM res...