The effects of chlorphenesin carbamate (CPC) and mephenesin on spinal neurons were investigated in spinal rats. CPC (50 mg/kg i.v.) inhibited the mono-(MSR) and poly-synaptic reflex (PSR), the latter being more susceptible than the former to CPC depression. Mephenesin also inhibited MSR and PSR, though the effects were short in duration. CPC had no effect on the dorsal root potential evoked by ...

Studies were carried out to elucidate the mechanism of action of chlorphenesin carbamate (CPC) and to compare the effect of the drug with that of mephenesin on the isolated bullfrog spinal cord. Ventral and dorsal root potentials were recorded by means of the sucrose-gap method. CPC caused marked hyperpolarizations and depressed spontaneous activities in both of the primary afferent terminals (...

This report describes a death related to the abuse of and intoxication by mephenesin. To the best of our knowledge, this is the first report case of lethal intoxication involving solely mephenesin and reporting mephenesin blood concentrations. The victim was a 48-year-old woman found unconscious at home. Resuscitation was unsuccessful. Toxicological analysis was performed on a blood sample coll...

A simple, specific, accurate and stability-indicating reversed phase high performance liquid chromatographic method was developed for the simultaneous determination of mephenesin and diclofenac diethylamine, using a Spheri-5-RP-18 column and a mobile phase composed of methanol: water (70:30, v/v), pH 3.0 adjusted with o-phosphoric acid. The retention times of mephenesin and diclofenac diethylam...

The possibility to use glycerol carbonate (GlyC) as an innovative alkylating agent for phenolic compounds in solventless conditions and the presence of a catalytic amount both homogeneous heterogeneous bases is herein described. In particular, peculiar, polyfunctional structure GlyC allows one obtain formation not only mono-phenoxy-1,2-propanediol (MPP) analogue but also 1,3-diphenoxy-2-propano...

FiG. 1. Effects of strychnine (100 tcg/kg, i.v.), mephenesin (30 mg/kg), pentobarbital (15 mg/kg), GABA (200 mg/kg) on the reflex response of the right cervical vagus nerve. In each series of record from above downwards : reflex responses to the stimulation of the left cervical vagus, great splanchnic and sciatic nerves. Strychnine (A) augmented and mephenesin (B) reduced mainly the reflex resp...

Mephenesin is an aromatic glycerol ether which decreases polysynaptic transmission in the spinal cord and brain stem. It is used as a skeletal muscle relaxant in the treatment of multiple sclerosis, Parkinson’s disease or acute muscle strain [1,2]. Mephenesin is associated to methyl nicotinate in the Décontractyl Balm. The methyl nicotinate has a rubifacient effect. Usually, the Décontractyl Ba...