APS (adaptor protein with PH and SH2 domains) initiates a phosphatidylinositol 3-kinase-independent pathway involved in insulin-stimulated glucose transport. We recently identified Enigma, a PDZ and LIM domain-containing protein, as a partner of APS and showed that APS-Enigma complex plays a critical role in actin cytoskeleton organization in fibroblastic cells. Because actin rearrangement is i...

This article describes a simplified cryptographic machine, based closely on the World War II Enigma. This ‘reduced Enigma’ exposes some of the design flaws of the original Enigma in a new way. Had the Axis powers built a reduced Enigma, the outcome of the war might have been different. A fully working reduced Enigma has been used very successfully in numerous public lectures, in school talks, a...

The Cbl proteins (Cbl, Cbl-b, and Cbl-c) are a highly conserved family of RING finger ubiquitin ligases (E3s) that function as negative regulators of tyrosine kinases in a wide variety of signal transduction pathways. In this study, we identify a new Cbl-c interacting protein, Enigma (PDLIM7). This interaction is specific to Cbl-c as Enigma fails to bind either of its closely related homologues...

The human E3 ubiquitin ligase murine double minute 2 (MDM2) targets the tumor suppressor p53 for ubiquitination and degradation but also promotes its own ubiquitination and subsequent degradation. As the balance between MDM2 and p53 levels plays a crucial role in regulating cell proliferation and apoptosis, we sought to identify factors selectively inhibiting MDM2 self-ubiquitination. Here we h...

El 18 de marzo 1939 se estrenó en el Cine Cuyás Las Palmas Gran Canaria la obra teatral enigma, una adaptación novela enigma los ojos grises, publicada por Josefina Torre bajo pseudónimo Laura Cominges editorial familiar La Novela Ideal. Este artículo aborda contexto creativo y proceso montaje publicidad que rodeó a pieza atribuida Claudio Torre, quien asumió dirección escénica. Además, estudia...

A fully working reduced Enigma has been used very successfully in numerous public lectures, in school talks, and in university seminars. Hands-on demonstrations of the reduced Enigma dramatically brings alive ideas about design, codes, permutations and groups. As a working trapdoor function, the reduced Enigma also provides an unusually clear introduction to public key cryptography. This articl...