The purpose of this study was to develop two novel drug delivery systems based on biodegradable docetaxel-lipid-based-nanosuspensions. The first one was poly(ethylene glycol)- modified docetaxel-lipid-based-nanosuspensions (pLNS). It was developed to increase the cycle time of the drug within the body and enhance the accumulation of the drug at the tumor site. The second one was targeted doceta...

Threshold-linear networks (TLNs) are models of neural networks that consist of simple, perceptron-like neurons and exhibit nonlinear dynamics that are determined by the network’s connectivity. The set of fixed points of a TLN, including both stable and unstable equilibria, plays a critical role in shaping its emergent dynamics. In this work, we provide two novel characterizations for the set of...

Antigen transport from the airway mucosa to the thoracic lymph nodes (TLNs) was studied in vivo by intratracheal instillation of fluorescein isothiocyanate (FITC)-conjugated macromolecules. After instillation, FITC(+) cells with stellate morphology were found deep in the TLN T cell area. Using flow cytometry, an FITC signal was exclusively detected in CD11c(med-hi)/major histocompatibility comp...

In developing the automated methodologies for simulation-based optimal shape designs, their accuracy, efficiency andpracticality are the defining factors to their success. To thatend, four recent improvements to the building blocks of such amethodology, intended for more practical designoptimization, have been reported. First, in addition to apolynomial-based parameteriz...

The recognition, internalization and intracellular processing of antigen are the main functions of dendritic cells (DCs). In the course of these processes, DCs differentiate and acquire the ability to produce cytokines responsible for polarization of the immunological response. Therefore, vaccination with tumor antigen-loaded DCs is one of the most promising approaches to induce tumor-specific ...

Correspondence: Tianfeng Chen 601, Huangpu Road, Guangzhou 510632, China Tel +86 20 8522 5962 Fax +86 20 8522 1263 Email [email protected] Concerning the recent articles published in your journal on multifunctional nanosystem for cancer chemotherapy. It should be an admirable approach to kill cancer cells, with the least side effects on normal tissues and cells. During the past few decades,...

The deformability of a compact object under the presence tidal perturbation is encoded in Love numbers (TLNs), which vanish for isolated black holes vacuum. We show that TLNs surrounded by matter fields do not and can be used to probe environment around binary holes. In particular, we compute case hole scalar condensate vector perturbations, finding strong power-law behavior TLN terms mass fiel...

A 1.8V, IMS/s, 8SdB SNR 2+2 mash ZA modulator with 10.9V reference voltage is realized by using the swing reduction sirnchue. Tlns smcture limits the output swing of all the integrators within half the reference voltage. Thus, low voltage and hgh speed operation is possible with even high reference voltage without degrading the performance of the modulator. The circuit is fabricated in CMOS 0.3...