There is currently a paucity of preclinical models available to study the metastatic process in esophageal cancer. Here we report FLO-1, and its isogenic derivative FLO-1LM, as two spontaneously metastatic cell line models of human esophageal adenocarcinoma. We show that FLO-1 has undergone epithelial-mesenchymal transition and metastasizes following subcutaneous injection in mice. FLO-1LM, der...

Background: The COVID-19 pandemic has forced many educational institutions to shift to flexible learning options (FLO), which require technology in teaching. Digital immigrant nurse educators, who are educators born before 1985, may need help adopting FLO due to their limited knowledge and skills in technology. This study aims to explore the experiences of digital immigrant nurse educators' cha...

In the Tabas coal preparation plant (SE Iran), -50 + 6 mm raw coal was treated in a 700 mm two-stage two-density Tri-Flo dynamic dense medium separator. In order to study the circuit performance and to evaluate the separator efficiency, 32 mm cubic density tracers were used in the range of 1.28-2.1 g/cm3 and under different operational conditions. The performance of Tri-Flo was evaluated in a r...

The outer cell wall of the yeast Saccharomyces cerevisiae serves as the interface with the surrounding environment and directly affects cell-cell and cell-surface interactions. Many of these interactions are facilitated by specific adhesins that belong to the Flo protein family. Flo mannoproteins have been implicated in phenotypes such as flocculation, substrate adhesion, biofilm formation, and...

This paper studies the recovery of a superposition of point sources from noisy bandlimited data.In the fewest possible words, we only have information about the spectrum of an object in the low-frequency band[−flo, flo] and seek to obtain a higher resolution estimate by extrapolating the spectrumup to a frequency fhi > flo. We show that as long as the sources are separated b...

This study evaluated the relationship between florfenicol resistance and flo genotypes in 1,987 Escherichia coli isolates from cattle. The flo gene was detected in 164 isolates, all of which expressed resistance to florfenicol at MICs of >/=256 microg/ml. The florfenicol MICs for all isolates that lacked flo were </=16 microg/ml.

The recessive lethal mutation flotte lotte (flo) disrupts development of the zebrafish digestive system and other tissues. We show that flo encodes the ortholog of Mel-28/Elys, a highly conserved gene that has been shown to be required for nuclear integrity in worms and nuclear pore complex (NPC) assembly in amphibian and mammalian cells. Maternal elys expression sustains zebrafish flo mutants ...

The flower meristem identity genes floricaula (flo) and squamosa (squa) promote a change in phyllotaxy from spiral to whorled in Antirrhinum. To determine how this might be achieved, we have performed a combination of morphological, genetic, and expression analyses. Comparison of the phenotypes and RNA expression patterns of single and double mutants with the wild type showed that flo and squa ...

Mechanisms whereby acid reflux may accelerate the progression from Barrett's esophagus (BE) to esophageal adenocarcinoma (EA) are not fully understood. Acid and reactive oxygen species (ROS) have been reported to cause DNA damage in Barrett's cells. We have previously shown that NADPH oxidase NOX5-S is responsible for acid-induced H2O2 production in Barrett's cells and in EA cells. In this stud...