نتایج جستجو برای: مدل elevated zero maze

تعداد نتایج: 443554  

ژورنال: :ارمغان دانش 0
محمود نارکی medicinal plants research center, yasuj university of medical sciences, yasuj, iran,مرکز تحقیقات گیاهان دارویی، دانشگاه علوم پزشکی یاسوج، یاسوج، ایران مهدی اکبرتبار طوری social determinants of health research center, yasuj university of medical sciences, yasuj, iranمرکز تحقیقات عوامل اجتماعی مؤثر بر سلامت، دانشگاه علوم پژشکی یاسوج، یاسوج، ایران لیلی سپهرآرا 3department of biology, kazeroon branch, islamic azad university, kazeroon, iranدانشگاه آزاد اسلامی واحد کازرون، کازرون، ایران محمدجعفر خجسته زاده 3department of biology, kazeroon branch, islamic azad university, kazeroon, iranدانشگاه آزاد اسلامی واحد کازرون، کازرون، ایران

زمینه و هدف: اختلالات اضطرابی از مشکلات عمده بشری است، تحقیق و جستجو بر ای یافتن داروهای مؤثر با عوارض جانبی کمتر ادامه دارد. آویشن شیرازی از گیاهان دارویی با اثرات درمانی گوناگون است که احتمال اثرات ضد اضطرابی برای آن وجود دارد. هدف از این مطالعه بررسی تأثیر رژیم غذایی حاوی برگ آویشن شیرازی بر رفتار اضطراب در موش صحرایی بود. روش بررسی: در این مطالعه تجربی تعداد 40 سر موش صحرایی نر بالغ نژاد وی...

پایان نامه :وزارت بهداشت، درمان و آموزش پزشکی - دانشگاه علوم پزشکی و خدمات بهداشتی درمانی استان کرمان 1389

چکیده ندارد.

پایان نامه :وزارت بهداشت، درمان و آموزش پزشکی - دانشگاه علوم پزشکی و خدمات بهداشتی درمانی استان کرمان 1387

چکیده ندارد.

2011
A. Sathish Kumar P. Amudha Satheesh Kannan

The present work is to evaluate the anxiolytic activity of a hydroalcoholic extract of Tephrosia purpuria (L) Pers (HAETP) in mice using the elevated plus-maze (EPM), elevated zero-maze (EZM), Y-maze and hole-board models. Furthermore, the anxiolytic effects of HAETP were compared to a known active anxiolytic drug diazepam. The extract, administered orally, in two different doses of HAETP 200 m...

Journal: :research in pharmaceutical sciences 0
f. hassanzadeh m. rabbani g.a. khodarahmi a. fasihi g.h hakimelahi m. mohajeri

based on the molecular modeling studies on two major families of anxiolytics and sedative hypnotics (benzodiazepines and barbiturates) a series of phthalimide derivatives were prepared from corresponding di-methyl phthalate derivatives in two steps, namely trans-amidification and ring closer of di-methyl phthalate with urea and base catalysed condensation of 4-bromobenzyl chloride and benzoyl c...

Journal: :مجله دانشگاه علوم پزشکی قم 0
شادی سرهرودی sh sarahroodi ahwaz jondishapour university of medical sciencesدانشگاه علوم پزشکی جندی شاپور اهواز اردشیر ارضی a arzi ahwaz jondishapour university of medical sciencesدانشگاه علوم پزشکی جندی شاپور اهواز محمدرضا زرین دست mr zarrindast tehran university of medical sciencesدانشگاه علوم پزشکی تهران محمد جواد خدایار mj khodayar ahwaz jondishapour university of medical sciencesدانشگاه علوم پزشکی جندی شاپور اهواز

background and objectives cannabinoids which are active compounds of marijuana show some pharmacological effects similar to the opioids. there are also functional interactions between both cannabinoid and opioid systems. in this study we investigated the role of cannabinoid receptors in central amygdala and its interaction with opioid system.   methods in the present study, we investigated the ...

Journal: :avicenna journal of neuro psycho physiology 0
zahra nemati neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran samaneh oveisi neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran alireza komaki neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran; department of physiology, school of medicine, hamadan university of medical sciences, hamadan, ir iran; department of physiology, school of medicine, hamadan university of medical sciences, p. o. box: 65178/518, hamadan, ir iran. tel: +98-8138380267, fax: +98-8138380131 siamak shahidi neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran

conclusions our results demonstrated that the extract of ob could induce anxiolytic effect in rats after 1 week oral administration. the effect of ob was not induced through changes in motor activity. further investigations are necessary for pharmacological providing of ob and better understanding of its anxiolytic properties and neurobiological mechanisms. results the results showed that after...

Journal: :iranian journal of pharmaceutical research 0
n naderi l tahmasb m kamalinejad

putative activity of hydroalcoholic and aqueous infusion extracts of echium amoenum l. was investigated in mice using the rotarod model of motor coordination and the elevated plus maze model of anxiety. the extracts were administered intraperitonealy (i.p.) once, one hour before performing the tests. preliminary phytochemical study of the plant, with standard procedures, showed that it contains...

Journal: :basic and clinical neuroscience 0
siamak shahidi nasrin hashemi-firouzi minoo mahmoodi

introduction: sildenafil, a phosphodiesterase-5 (pde5) inhibitor, may have various effects on the central nervous system via the nitric oxide (no)-cyclic guanosine monophosphate (cgmp) pathway. preclinical studies have shown the controversial effect of sildenafil on anxiety-like behavior in animals. this study was undertaken to investigate the acute effect of sildenafil on anxiety-like behavior...

2002
Richard E. Brown Stephanie C. Corey Angela K. Moore

MHC-congenic mice prefer to mate with mice of different MHC types and are able to discriminate between MHC-congenic mice by their urine odors, but nothing is known about behavioral differences among MHC-congenic mice. The present experiments examine the strain and sex differences in MHC-congenic C57BL/6J and B6-H-2K mice with respect to exploration and fear motivated behaviors in the elevated p...

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