Sulindac (SLD) is a nonsteroidal anti-inflammatory drug (NSAID) that has been associated with a greater incidence of idiosyncratic hepatotoxicity in human patients than other NSAIDs. In previous studies, cotreatment of rats with SLD and a modestly inflammatory dose of lipopolysaccharide (LPS) led to liver injury, whereas neither SLD nor LPS alone caused liver damage. In studies presented here, ...

The search space of SLD resolution, usually represented by means of a socalled SLD tree, is often infinite. However, there are many applications that must deal with possibly infinite SLD trees, like partial evaluation or some static analyses. In this context, being able to construct a finite representation of an infinite SLD tree becomes useful. In this work, we introduce a framework to constru...

Experimental examination of the gyroscopic and rotary inertia effects on the chatter boundary in a milling operation is the chief aim of this article. The equations of motion of the tool vibration are derived based on Timoshenko beam theory and Hamilton principle by considering gyroscopic moment, rotary inertia, velocity-dependent process damping and radial immersion effect. For a range of dept...

This paper defines strongly language disjoint (SLD) checkers. SLD checkers are to sequential systems what strongly code disjoint checkers are to combinational systems. SLD checkers are the largest class of checkers with which a functional system may achieve the TSC goal. Self-checking sequential systems are first addressed, then formal definitions of SLD checkers are given. The next point is th...

The marine natural product 12-epi-scalaradial (SLD) is a specific secretory phospholipase A(2) (sPLA(2)) inhibitor. However, little is known about whether this compound has other pharmacological effects. Here, we revealed a novel effect of SLD on epidermal growth factor receptor (EGFR)-mediated Akt phosphorylation. SLD dose- and time-dependently inhibited epidermal growth factor (EGF)-stimulate...

Sl/Sld mice have a defective hemopoietic microenvironment. It has been assumed, based upon previous studies, that the primary abnormality in these mice is simply lack of a necessary supportive or inductive material within the hemopoietic stroma. We used in vitro long-term bone marrow cultures to characterize further the nature of the hemopoietic microenvironmental defect in Sl/Sld mice. Sl/Sld ...